Komparativna klinička, imunološka, citogenetska i kariometrijska analiza akutnih leukemija

Abstract

Acute myeloid leukemia (AML) is a malignant disease with fulminant course, which results in a high percentage of patients remaining unfavourable. The aim of our researche is to define potentially new prognostic factors and to campare them with standard, well established, prognostic factors in AML. Study group included 123 newly diagnosed patients, with mean age about 65yr., with diagnosis AML Mo-M5, according to FAB classification. After diagnosis, all patients underwent karyometricanalyses (eg. measure of leukemic blast nuclei parameters), convenctional karyotype analysis, molecular analyses of FLT3 ITD mutation, as well as immunofenotype analisis by flow cytometry. According to results, it can be concluded that the main adverse actors in AML are: advanced age of patient, leucopenia or white blood cells count higher than 100000 x 10 on 9th/1 presence of FLT3 ITD mutation and higher siye of myeloblast's nuclei.