Populaciona farmakokinetika 25-hidroksi vitamina D kod studenata
Population pharmacokinetics of 25-hydroxy vitamin D in students
dc.contributor.advisor | Milovanović, Jasmina | |
dc.contributor.other | Janković, Slobodan | |
dc.contributor.other | Veličković Stošić, Radmila | |
dc.contributor.other | Kostić, Marina J. | |
dc.contributor.other | Jović-Stošić, Jasmina | |
dc.creator | Milovanović, Olivera Z. | |
dc.date.accessioned | 2016-01-05T13:10:17Z | |
dc.date.available | 2016-01-05T13:10:17Z | |
dc.date.available | 2020-07-03T15:17:52Z | |
dc.date.issued | 2015-02-09 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/3752 | |
dc.identifier.uri | http://eteze.kg.ac.rs/application/showtheses?thesesId=1794 | |
dc.identifier.uri | https://fedorakg.kg.ac.rs/fedora/get/o:460/bdef:Content/download | |
dc.description.abstract | Vitamin D, jedan od liposolubilnih vitamina, predstavlja sferu interosavanja naučnih istraživanja usled plejade efekata koje ostvaruje u ljudskom organizmu. Epidemijske razmere hipovitaminoze D širom sveta u različitim starosnim grupama predstavljaju zabrinjavajući podatak. Sprovedena studija je bila po tipu serije slučajeva i imala je cilj da izvrši populacionu farmamkokinetičku analizu 25-hidroksi vitamina D kod studenata Fakulteta medicinskih nauka, Univerziteta u Kragujevcu, pomoću NONMEMA- softverskog programa. Sprovedena analiza je imala za cilj da precizno definiše farmakokinetički model klirensa 25-hidroksi vitamina D u ispitivanoj populaciji tj. da opiše srednju populacionu vrednost klirensa ispitivane supstance, intra- i interindividualnu varijabilnost kao i da definiše faktore koji utiču na srednju, populacionu vrednost klirensa. Pored navedenog studija je ispitivala uticaj statusa vitamina D na prosečnu ocenu ostvarenu na studijama, nivo anksioznosti, depresivnosti i kogniciju. Rezultati sprovedenog istraživanja pokazuju značajan uticaj dva faktora na prosečnu vrednost klirensa 25-hidroksi vitamina D kod studenata a to su prosečna doza vitamina D uneta hranom i serumski nivo fosfata. Serumska koncentracija vitamina D nije pokazala statistički značajan uticaj na prosečnu ocenu na studijama, kao ni na nivo anksioznosti, depresivnosti i kognice. Režim ishrane, tj. koznumiranje ribljih proizvoda je uticalo na serumski nivo 25- hidroksi vitamina D kod ispitanika. Dobijeni farmakokinetički model klirensa 25-hidroksi vitamina D može biti od koristi kod suplementacije vitaminom D u mladoj, zdravoj, studentskoj populaciji. | sr |
dc.description.abstract | Vitamin D, a fat-soluble vitamin, is a sphere of scientific research due to multiple effects that he achieved at the human body. Epidemic proportion of hypovitaminosis D all over the world at the different age groups is alarming fact. Conducted research, that was case series by type, had aim to carry out population pharmacokinetics analisys of 25-hydroxy vitamin D at students population at the Faculty of Medical Scineces, University of Kragujevac, by using NONMEM- software program. This analysis should exact defined pharmacokinetics model of clearance of 25-hydroxy vitamin D in examined population and describe mean population value of clearance and value of intra- and interindividual variability. Conducted analysis should idetificate factors that have significant influence on mean, population value of clearance of 25-hydroxy vitamin D. Additionally aim of study was to determine influence of serum 25-hydroxy vitamin D concentration on the average school scores, anxiety, depression and cognition level. The study results showed that two factors had important influence on mean, population value of clearance of 25-hydroxy vitamina D and that was mean daily vitamin D intake by food and serum phosphate levels. Serum concentration of 25- hydroxy vitamin D did not show significant influence on average school score and anxiety, depression and cognition levels.Fish consumption has influence on serum 25- hydroxy vitamin D levels. Obtained pharmacokinetics clearance model of 25-hydroxy vitamin D could be used for vitamin D supplementation at young, healthy, student’s population. | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Крагујевцу, Факултет медицинских наука | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175014/RS// | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Универзитет у Крагујевцу | sr |
dc.subject | 25-hidroksi vitamin D | sr |
dc.subject | 25-hydroxy vitamin D | en |
dc.subject | 1 | en |
dc.subject | 25- dixydroxy vitamin D | en |
dc.subject | Population pharmacokinetics | en |
dc.subject | NONMEM | en |
dc.subject | students | en |
dc.subject | 1 | sr |
dc.subject | 25-dihidroksi vitamin D | sr |
dc.subject | populaciona farmakokinetika | sr |
dc.title | Populaciona farmakokinetika 25-hidroksi vitamina D kod studenata | sr |
dc.title | Population pharmacokinetics of 25-hydroxy vitamin D in students | en |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Миловановић, Јасмина; Јанковић, Слободан; Величковић Стошић, Радмила; Костић, Марина Ј.; Јовић-Стошић, Јасмина; Миловановић, Оливера З.; Популациона фармакокинетика 25-хидрокси витамина Д код студената; Популациона фармакокинетика 25-хидрокси витамина Д код студената; | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/49384/Disertacija.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/49385/olivera_milovanovic_07.11.2014.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/49384/Disertacija.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/49385/olivera_milovanovic_07.11.2014.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_3752 |