Show simple item record

Population pharmacokinetics of 25-hydroxy vitamin D in students

dc.contributor.advisorMilovanović, Jasmina
dc.contributor.otherJanković, Slobodan
dc.contributor.otherVeličković Stošić, Radmila
dc.contributor.otherKostić, Marina J.
dc.contributor.otherJović-Stošić, Jasmina
dc.creatorMilovanović, Olivera Z.
dc.date.accessioned2016-01-05T13:10:17Z
dc.date.available2016-01-05T13:10:17Z
dc.date.available2020-07-03T15:17:52Z
dc.date.issued2015-02-09
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/3752
dc.identifier.urihttp://eteze.kg.ac.rs/application/showtheses?thesesId=1794
dc.identifier.urihttps://fedorakg.kg.ac.rs/fedora/get/o:460/bdef:Content/download
dc.description.abstractVitamin D, jedan od liposolubilnih vitamina, predstavlja sferu interosavanja naučnih istraživanja usled plejade efekata koje ostvaruje u ljudskom organizmu. Epidemijske razmere hipovitaminoze D širom sveta u različitim starosnim grupama predstavljaju zabrinjavajući podatak. Sprovedena studija je bila po tipu serije slučajeva i imala je cilj da izvrši populacionu farmamkokinetičku analizu 25-hidroksi vitamina D kod studenata Fakulteta medicinskih nauka, Univerziteta u Kragujevcu, pomoću NONMEMA- softverskog programa. Sprovedena analiza je imala za cilj da precizno definiše farmakokinetički model klirensa 25-hidroksi vitamina D u ispitivanoj populaciji tj. da opiše srednju populacionu vrednost klirensa ispitivane supstance, intra- i interindividualnu varijabilnost kao i da definiše faktore koji utiču na srednju, populacionu vrednost klirensa. Pored navedenog studija je ispitivala uticaj statusa vitamina D na prosečnu ocenu ostvarenu na studijama, nivo anksioznosti, depresivnosti i kogniciju. Rezultati sprovedenog istraživanja pokazuju značajan uticaj dva faktora na prosečnu vrednost klirensa 25-hidroksi vitamina D kod studenata a to su prosečna doza vitamina D uneta hranom i serumski nivo fosfata. Serumska koncentracija vitamina D nije pokazala statistički značajan uticaj na prosečnu ocenu na studijama, kao ni na nivo anksioznosti, depresivnosti i kognice. Režim ishrane, tj. koznumiranje ribljih proizvoda je uticalo na serumski nivo 25- hidroksi vitamina D kod ispitanika. Dobijeni farmakokinetički model klirensa 25-hidroksi vitamina D može biti od koristi kod suplementacije vitaminom D u mladoj, zdravoj, studentskoj populaciji.sr
dc.description.abstractVitamin D, a fat-soluble vitamin, is a sphere of scientific research due to multiple effects that he achieved at the human body. Epidemic proportion of hypovitaminosis D all over the world at the different age groups is alarming fact. Conducted research, that was case series by type, had aim to carry out population pharmacokinetics analisys of 25-hydroxy vitamin D at students population at the Faculty of Medical Scineces, University of Kragujevac, by using NONMEM- software program. This analysis should exact defined pharmacokinetics model of clearance of 25-hydroxy vitamin D in examined population and describe mean population value of clearance and value of intra- and interindividual variability. Conducted analysis should idetificate factors that have significant influence on mean, population value of clearance of 25-hydroxy vitamin D. Additionally aim of study was to determine influence of serum 25-hydroxy vitamin D concentration on the average school scores, anxiety, depression and cognition level. The study results showed that two factors had important influence on mean, population value of clearance of 25-hydroxy vitamina D and that was mean daily vitamin D intake by food and serum phosphate levels. Serum concentration of 25- hydroxy vitamin D did not show significant influence on average school score and anxiety, depression and cognition levels.Fish consumption has influence on serum 25- hydroxy vitamin D levels. Obtained pharmacokinetics clearance model of 25-hydroxy vitamin D could be used for vitamin D supplementation at young, healthy, student’s population.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Крагујевцу, Факултет медицинских наукаsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175014/RS//
dc.rightsopenAccessen
dc.sourceУниверзитет у Крагујевцуsr
dc.subject25-hidroksi vitamin Dsr
dc.subject25-hydroxy vitamin Den
dc.subject1en
dc.subject25- dixydroxy vitamin Den
dc.subjectPopulation pharmacokineticsen
dc.subjectNONMEMen
dc.subjectstudentsen
dc.subject1sr
dc.subject25-dihidroksi vitamin Dsr
dc.subjectpopulaciona farmakokinetikasr
dc.titlePopulaciona farmakokinetika 25-hidroksi vitamina D kod studenatasr
dc.titlePopulation pharmacokinetics of 25-hydroxy vitamin D in studentsen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dcterms.abstractМиловановић, Јасмина; Јанковић, Слободан; Величковић Стошић, Радмила; Костић, Марина Ј.; Јовић-Стошић, Јасмина; Миловановић, Оливера З.; Популациона фармакокинетика 25-хидрокси витамина Д код студената; Популациона фармакокинетика 25-хидрокси витамина Д код студената;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/49385/olivera_milovanovic_07.11.2014.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/49384/Disertacija.pdf


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record