Uticaj lekova na nivo TSH kod pacijenata na supstitucionoj terapiji tiroksinom

Abstract

Hypothyroidism requires thyroxine replacement, regardlesss thyroidectomy was performed or not. The goal of this research was to determine how different groups of drugs – ACE inhibitors, selective beta blockators, Ca antagonists, nitrates, statins, or different combinations of these drugs affect TSH level at the patients on the thyroxine replacement therapy after total thyroidectomy. Research took place in 2012 and was performed on the outpatients that check their chormones at Department of Nuclear Medicine in Clinical Center Kragujevac. 247 patients were divided into groups depending on which drugs they had been prescribed. The control group involved patients taking just thyroxine without other medication. TSH level of patients in control group was compared with TSH level of patients in groups taking other drugs. Our study showed that patients that use selective beta bloskators have significantly higher level of TSH than patients that don’t take these drugs. TSH level in the grops of patients using all other drugs did not differ from the control group.