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Sinteza i karakterizacija kompleksa zlata(III) sa nekim dipeptidima

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2012
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Author
Glišić, Biljana Đ.
Mentor
Đuran, Miloš I.
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Abstract
Nakon otkrića antitumorske aktivnosti cisplatine, posebna pažnja je posvećena ispitivanju kompleksa zlata(III) kao potencijalnih antitumorskih agenasa, zbog činjenice da su Au(III) i Pt(II) izoelektronski joni (d8 elektronska konfiguracija) i da formiraju kvadratno-planarne komplekse. Usled potencijalne primene kompleksa zlata(III) u lečenju tumora, u toku poslednjih nekoliko decenija,intenzivno su izučavane reakcije Au(III) jona sa biološki važnim ligandima, kao što su aminokiseline, peptidi i proteini. Mehanizam antitumorskog delovanja kompleksa zlata(III) još uvek nije u potpunosti razjašnjen i predstavlja predmet intenzivnih izučavanja. Ispitivanje reakcija kompleksa zlata(III) sa peptidima je od velikog značaja za definisanje mehanizma antitumorskog i toksičnog delovanja ovih kompleksa.
After discovery of the anticancer properties of cisplatin, special attention was devoted to evaluation of gold(III) complexes as potential antitumor agents due to the fact that both Pt(II) and Au(III) ions possess the same d8 electronic configuration and preferentially form square-planar complexes. The possible involvement of gold(III)complexes in cancer treatment initiated an interest in the area of gold(III) interactions with different biologically important ligands such as amino acids, peptides and proteins. However, the mechanism of antitumor activity of gold(III) complexes is not yet completely understood and further investigation of this subject is required. A better knowledge of the gold(III) reactions with peptides contributes to the future development of gold(III) complexes as potential antitumor agents and also has importance in relation to the severe toxicity of gold-based drugs.
Faculty:
Универзитет у Крагујевцу, Природно-математички факултет
Date:
02-11-2012
Projects:
  • Synthesis of new metal complexes and investigation of their reactions with peptides (RS-172036)
Keywords:
zlato(III) kompleksi

DOI: 10.2298/kg20121102glisic

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_3572
URI
http://eteze.kg.ac.rs/application/showtheses?thesesId=54
https://nardus.mpn.gov.rs/handle/123456789/3572
https://fedorakg.kg.ac.rs/fedora/get/o:116/bdef:Content/download

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