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Synthesis, characterizaon and potenal cytotoxity of o,o'-dialkil-(s,s)-ethilenediamine-n,n'- di--2-(4-methyl)-pentanoate and the corresponding palladium(ii), planum(ii) and planum(iv) complexes

dc.contributor.advisorTrifunović, Srećko R.
dc.contributor.otherKaluđerović, Goran N.
dc.contributor.otherSabo, Tibor J.
dc.contributor.otherArsenijević, Nebojša
dc.contributor.otherPetrović, Biljana V.
dc.creatorVujić, Jelena M.
dc.date.accessioned2016-01-05T13:05:31Z
dc.date.available2016-01-05T13:05:31Z
dc.date.available2020-07-03T15:06:39Z
dc.date.issued2012-09-14
dc.identifier.urihttp://eteze.kg.ac.rs/application/showtheses?thesesId=82
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/3563
dc.identifier.urihttps://fedorakg.kg.ac.rs/fedora/get/o:136/bdef:Content/download
dc.description.abstractThis works describes synthesis, characterization and potential cytotoxity of O,O'- -dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid, [(S,S)-H4eddl]Cl2, as well as their corresponding palladium(II), platinum(II) and platinum(IV) complexes. Esters (S,S)-R2eddl·2HCl (R = ethyl, n-propyl, n-butyl and n-pentyl) were obtained by instillation of thionyl chloride in an appropriate absolute alcohol, and then refluxing with addition of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid. All of the esters were obtained as dihydrochlorides: (S,S)-Et2eddl·2HCl, (S,S)-Pr2eddl·2HCl, (S,S)-Bu2eddl·2HCl, (S,S)-Pe2eddl·2HCl. Esters were characterized by elemental analysis, IR and NMR spectroscopy, and in the case of (S,S)-Pr2eddl·2HCl the structure was confirmed by X-ray structural analysis.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Крагујевцу, Природно-математички факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Крагујевцуsr
dc.subjectPaladijum(II) kompleksisr
dc.subjectPlatina(II) kompleksien
dc.subjectPalatina(IV) kompleksien
dc.titleSinteza, karakterizacija i potencijalna citotoksičnost O,O'-dialkil-(S,S)-etilendiamin-N,N'-DI-2-(4-metil)-pentanoati i odgovarajućih paladijum(II), platina(II) i platina (IV) kompleksasr
dc.titleSynthesis, characterizaon and potenal cytotoxity of o,o'-dialkil-(s,s)-ethilenediamine-n,n'- di--2-(4-methyl)-pentanoate and the corresponding palladium(ii), planum(ii) and planum(iv) complexesen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dcterms.abstractТрифуновић, Срећко Р.; Петровић, Биљана В.; Калуђеровић, Горан Н.; Aрсенијевић, Небојша; Сабо, Тибор Ј.; Вујић, Јелена М.; Синтеза, карактеризација и потенцијална цитотоксичност О,О'-диалкил-(С,С)-етилендиамин-Н,Н'-ДИ-2-(4-метил)-пентаноати и одговарајућих паладијум(ИИ), платина(ИИ) и платина (ИВ) комплекса; Синтеза, карактеризација и потенцијална цитотоксичност О,О'-диалкил-(С,С)-етилендиамин-Н,Н'-ДИ-2-(4-метил)-пентаноати и одговарајућих паладијум(ИИ), платина(ИИ) и платина (ИВ) комплекса;
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/47008/Disertacija.pdf
dc.identifier.doi10.2298/kg20120914vujic
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_3563


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