Sinteza, karakterizacija i potencijalna citotoksičnost O,O'-dialkil-(S,S)-etilendiamin-N,N'-DI-2-(4-metil)-pentanoati i odgovarajućih paladijum(II), platina(II) i platina (IV) kompleksa
Synthesis, characterizaon and potenal cytotoxity of o,o'-dialkil-(s,s)-ethilenediamine-n,n'- di--2-(4-methyl)-pentanoate and the corresponding palladium(ii), planum(ii) and planum(iv) complexes
Doktorand
Vujić, Jelena M.Mentor
Trifunović, Srećko R.Članovi komisije
Kaluđerović, Goran N.Sabo, Tibor J.
Arsenijević, Nebojša
Petrović, Biljana V.
Metapodaci
Prikaz svih podataka o disertacijiSažetak
This works describes synthesis, characterization and potential cytotoxity of O,O'-
-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid, [(S,S)-H4eddl]Cl2, as well as their corresponding palladium(II), platinum(II) and platinum(IV) complexes. Esters (S,S)-R2eddl·2HCl (R = ethyl, n-propyl, n-butyl and n-pentyl) were obtained by instillation of thionyl chloride in an appropriate absolute alcohol, and then refluxing with addition of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid. All of the esters were obtained as dihydrochlorides: (S,S)-Et2eddl·2HCl, (S,S)-Pr2eddl·2HCl, (S,S)-Bu2eddl·2HCl,
(S,S)-Pe2eddl·2HCl. Esters were characterized by elemental analysis, IR and NMR
spectroscopy, and in the case of (S,S)-Pr2eddl·2HCl the structure was confirmed by X-ray structural analysis.
Fakultet:
Универзитет у Крагујевцу, Природно-математички факултетDatum odbrane:
14-09-2012Projekti:
- Sinteza, modelovanje, fizičko-hemijske i biološke osobine organskih jedinjenja i odgovarajućih kompleksa metala (RS-MESTD-Basic Research (BR or ON)-172016)