Sinteza, karakterizacija i potencijalna citotoksičnost O,O'-dialkil-(S,S)-etilendiamin-N,N'-DI-2-(4-metil)-pentanoati i odgovarajućih paladijum(II), platina(II) i platina (IV) kompleksa
Synthesis, characterizaon and potenal cytotoxity of o,o'-dialkil-(s,s)-ethilenediamine-n,n'- di--2-(4-methyl)-pentanoate and the corresponding palladium(ii), planum(ii) and planum(iv) complexes
Author
Vujić, Jelena M.Mentor
Trifunović, Srećko R.Committee members
Kaluđerović, Goran N.Sabo, Tibor J.
Arsenijević, Nebojša
Petrović, Biljana V.
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This works describes synthesis, characterization and potential cytotoxity of O,O'-
-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid, [(S,S)-H4eddl]Cl2, as well as their corresponding palladium(II), platinum(II) and platinum(IV) complexes. Esters (S,S)-R2eddl·2HCl (R = ethyl, n-propyl, n-butyl and n-pentyl) were obtained by instillation of thionyl chloride in an appropriate absolute alcohol, and then refluxing with addition of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid. All of the esters were obtained as dihydrochlorides: (S,S)-Et2eddl·2HCl, (S,S)-Pr2eddl·2HCl, (S,S)-Bu2eddl·2HCl,
(S,S)-Pe2eddl·2HCl. Esters were characterized by elemental analysis, IR and NMR
spectroscopy, and in the case of (S,S)-Pr2eddl·2HCl the structure was confirmed by X-ray structural analysis.