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Study of electrochemical activity and transformations macrolides antibiotics

dc.contributor.advisorPetrović, Slobodan D.
dc.contributor.otherAvramov Ivić, Milka
dc.contributor.otherVajs, Vlatka
dc.contributor.otherVladimirov, Sote
dc.contributor.otherMijin, Dušan
dc.creatorDrljević-Đurić, Katica M.
dc.date.accessioned2016-01-05T12:43:00Z
dc.date.available2016-01-05T12:43:00Z
dc.date.available2020-07-03T09:22:21Z
dc.date.issued2011-06-21
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=1174
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/2943
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:8037/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=45053199
dc.description.abstractCilj ove disertacije bio je da se ispitivanjem elektrohemijske aktivnosti makrolidnih antibiotika roksitromicina i midekamicina i poredjenjem dobijenih rezultata sa rezultatima ranije ispitanih azitromicina, klaritromicina i eritromicina izvede opšti zaključak o elektrohemijskom ponašanju ispitanih makrolidnih antibiotika, njihovim mogućim elektrohemijskim transformacijama kao i o mogućnosti njihovog kvalitativnog i kvantitativnog odredjivanja. Posebno je razmatrana mogućnost primene novih voltametrijskih metoda za odredjivanja makrolidnih antibiotika kao sastojaka komercijalnih i bioloških uzoraka. Na osnovu detaljnog ispitivanja elektrohemijskog ponašanja roksitromicina metodama ciklične voltametrije i diferencijalne pulsne voltametrije i midekamicina metodom ciklične voltametrije na elektrodi od zlata, simultano praćeno HPLC i LC/MS metodama kvalitativno i kvantitativno analitički su određene farmaceutske supstance roksitromicin i midekamicin, a roksitromicin i kao sastojak komercijalnog roksitromicina (Runac® tablete) i biološke tečnosti (humani urin). Poredjenjem sa ranije ispitivanim makrolidnim antibioticima pod istim uslovima, utvrdjeno je da su azitromicin, roksitromicin i midekamicin kvalitativno i kvantitativno analitički određeni. Eritromicin i klaritromicin su određeni kvalitativno a transformacije kojima podležu, za razliku od azitromicina, roksitromicina i midekamicina su praćene FTIR i HPLC metodama.sr
dc.description.abstractThe aim of the present PhD thesis was to examinate the electrochemical activity of macrolide antibiotics roxithromycin and midecamyin and to compare with the previously investigated azithromycin, clarithromycin and erithromycin in order to have general conclusion concerning electrochemical behavior of macrolide antibiotics. That means, their possible electrochemical transformations as well as the possibility of their quantitative and qualitative determination. Separetely was analysed the possibility of the new voltammetric methods application for the determination of macrolide antibiotics and as a content of commercial an biological samples. Taking into account the detailed investigation of the electrochemical behavior of roxithromycin by cyclic voltammetry and differential pulse voltammetry and a midecamyin by cyclic voltammetry on gold electrode by simultaneous detection of antibiotics by HPLC and LC/MS methods. Their standards were quantitatively and qualitatively were determined and roxithromycin was determined in the same manner and as a content of commercial tablets Runac® and as content of humane urine. The comparison with the previously investigated macrolide antibiotics under the identical experimental conditions, shown that azithromycin, roxithromycin and midecamyin are succesfully quantitatively and qualitatively determined. Clarithromycin and erithromycin undergo to the electrochemical transformations during the qualitative determination and these transformations were simultaneosly followed by HPLC and FTIR methods.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Технолошко-металуршки факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectmakrolidni antibioticisr
dc.subjectmacrolide antibioticsen
dc.subjectroxithromycinen
dc.subjectmidecamycinen
dc.subjectelectrochemical behaviouren
dc.subjectcyclic voltammetryen
dc.subjectdifferential pulse voltammetryen
dc.subjecthigh performance liquid chromatographyen
dc.subjectmass spectrometryen
dc.subjectelektrohemijsko ponašanjesr
dc.subjectroksitromicinsr
dc.subjectmidekamicinsr
dc.subjectciklična voltametrijasr
dc.subjectdiferencijalna pulsna voltametrijasr
dc.subjectvisoko efikasna tečna hromatografijasr
dc.subjectmasena spektrometrijasr
dc.titleProučavanje elektrohemijske aktivnosti i transformacija makrolidnih antibiotikasr
dc.titleStudy of electrochemical activity and transformations macrolides antibioticsen
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dcterms.abstractПетровић, Слободан Д.; Вајс, Влатка; Мијин, Душан; Владимиров, Соте; Aврамов Ивић, Милка; Дрљевић-Ђурић, Катица М.; Проучавање електрохемијске активности и трансформација макролидних антибиотика; Проучавање електрохемијске активности и трансформација макролидних антибиотика;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/17920/Disertacija.pdf


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