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The influence of age, estrogen status and carotid atherosclerosis on dental pulp blood flow

dc.contributor.advisorStojić, Dragica
dc.contributor.otherKršljak, Elena
dc.contributor.otherLukić, Aleksandra
dc.contributor.otherGrga, Đurica
dc.contributor.otherJapundžić-Žigon, Nina
dc.creatorDželetović, Bojan D.
dc.date.accessioned2016-01-05T12:14:39Z
dc.date.available2016-01-05T12:14:39Z
dc.date.available2020-07-03T09:13:59Z
dc.date.issued2012-07-17
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=99
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/2681
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:3774/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=42651151
dc.description.abstractZubna pulpa predstavlja mikrocirkulatorni sistem koji zbog svoje lokalizacije unutar čvrstih dentinskih zidova ima posebne karakteristike. Glavni dovodni krvni sudovi za zubnu pulpu, kao i druge organe i tkiva orofacijalne regije, su zajednička karotidna arterija (ZKA) i spoljašnja karotidna arterija (SKA). Karotidne arterije, kao i mikrocirkulacija zubne pulpe starenjem podležu različitim strukturnim i funkcionalnim promenama. Pokazano je da fiziološke promene nivoa estrogena u plazmi tokom menstrualnog ciklusa, kao i u menopauzi, značajno utiču na protok krvi u mikrocirkulatornim sistemima mozga i kože. U patološkim uslovima, u prisustvu ateroskleroze karotidnih arterija, postoje značajne promene u protoku krvi u tkivima koja one ishranjuju. Imajući sve ovo u vidu postavljena je hipoteza da životna dob, estrogenski status i ateroskleroza karotidnih arterija značajno utiču na protok krvi u zubnoj pulpi. Ciljevi ovog istraživanja bili su: 1. Odrediti protok krvi kroz krvne sudove zubne pulpe i protok kroz ZKA i SKA kao i debljinu intimo-medijalnog kompleksa (IMK) pomenutih arterija kod zdravih osoba, oba pola, u dve starosne grupe, od 20-25 i od 50- 60 godina (opšta populacija); 2. Ispitati zavisnost protoka krvi u zubnoj pulpi, protoka kroz ZKA i SKA kao i debljine IMK pomenutih arterija u odnosu na životnu dob kod opšte populacije; 3. Ispitati korelaciju između protoka krvi kroz krvne sudove zubne pulpe i protoka kroz ZKA i SKA i debljine IMK pomenutih arterija kod opšte populacije; 4. Odrediti protok krvi kroz krvne sudove zubne pulpe i nivo estrogena kod zdravih žena starosti od 20-25 godina u toku redovnog menstrualnog ciklusa (koji traje 28 dana), u fazi kada je visok estrogen (od 10. do 13. dana) i u fazi niskog estrogena (od 26. do 5. dana), kao i kod žena u menopauzi; 5. Ispitati korelaciju između protoka krvi u krvnim sudovima zubne pulpe i estrogenskog statusa žena sa redovnim menstrualnim ciklusom i žena u menopauzisr
dc.description.abstractDental pulp represents a microcirculatory sistem which due to localization within dentinal walls has specific characteristics. Major feeding blood vesels of dental pulp, as well as orofacial region, are common carotid artery (CCA) and external carotid artery (ECA). Carotid arteries, like dental pulp microcirculation, undergo different structural and functional age-related changes. It has been shown that physiological changes in plasma estrogen levels during the menstrual cycle, and postmenopause, significantly affect blood flow in the microcirculatory system of the brain and skin. In pathological conditions, in presence of carotid atherosclerosis, there are significant changes in blood flow in tissues they supply. Having all this in mind, it was hypothesized that age, estrogen status and carotid atherosclerosis significantly affect blood flow in the dental pulp. The aims of this study were to: 1. Determine dental pulp blood flow and blood flow through the CCA and ECA and intima-media thickness (IMT) of these arteries in healthy adults of both sexes in two age groups of 20-25 and 50-60 years (general population); 2. Examine the dependence of dental pulp blood flow, the flow through the CCA and ECA, and IMT of these arteries in relation to age in the general population; 3. Examine the correlation between dental pulp blood flow and flow through the CCA and ECA and IMT of these arteries in the general population; 4. Determine dental pulp blood flow and estrogen levels in healthy women aged 20-25 years during the regular menstrual cycle (which is 28 days), at a phase when estrogen is high (from 10 to 13 days) and a phase when estrogen is low (from 26 to 5 days), and in postmenopausal women; 5. Examine the correlation between dental pulp blood flow and estrogen levels in women with regular menstrual cycle and postmenopausal women...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Стоматолошки факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175021/RS//
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectprotok krvi u zubnoj pulpisr
dc.subjectdental pulp blood flowen
dc.subjectstarenjesr
dc.subjectestrogensr
dc.subjectkarotidna aterosklerozasr
dc.subjectspektralna Vejvlet analizasr
dc.subjectageingen
dc.subjectestrogenen
dc.subjectcarotid atherosclerosisen
dc.subjectspectral analysisen
dc.subjectwavelet analysisen
dc.titleUticaj životne dobi, estrogenskog statusa i karotidne ateroskleroze na protok krvi kroz zubnu pulpusr
dc.titleThe influence of age, estrogen status and carotid atherosclerosis on dental pulp blood flowen
dc.typedoctoralThesis
dc.rights.licenseBY-NC
dcterms.abstractСтојић, Драгица; Грга, Ђурица; Кршљак, Елена; Лукић, Aлександра; Јапунджић-Жигон, Нина; Джелетовић, Бојан Д.; Утицај животне доби, естрогенског статуса и каротидне атеросклерозе на проток крви кроз зубну пулпу; Утицај животне доби, естрогенског статуса и каротидне атеросклерозе на проток крви кроз зубну пулпу;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/15925/Disertacija.pdf


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