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Quality of life assessment in children and adolescents with primary immunodeficiencies

dc.contributor.advisorPašić, Srđan
dc.contributor.otherPekmezović, Tatjana
dc.contributor.otherMatejić, Bojana
dc.contributor.otherPantović, Vesna
dc.creatorKuburović, Nina B.
dc.date.accessioned2016-01-05T12:07:11Z
dc.date.available2016-01-05T12:07:11Z
dc.date.available2020-07-03T08:51:21Z
dc.date.issued2014-05-21
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/2475
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=1915
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:9628/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=46743311
dc.description.abstractUvod: Kvalitet ţivota povezan sa zdravljem (engl. health-related quality of life, HRQOL) predstavlja multidimenzionalni koncept i obuhvata fizičku, emocionalnu, psihosocijalnu i bihejvioralnu komponentu blagostanja i funkcionisanja, te se danas sve više prepoznaje kao deo multimodalne procene zdravlja i ishoda lečenja dece sa hroničnim bolestima, uključujući i decu sa primarnim imunodeficijencijama (PID). Cilj: Osnovni cilj istraţivanja je bio da se proceni HRQOL, nivo anksioznosti i depresivnosti kod dece sa PID, kao i da se utvrdi na koji način emocionalni problemi ove dece utiču na njihov kvalitet ţivota. Metode: Istraţivanje je sprovedeno po tipu studije preseka i obuhvatilo je 25 bolesnika sa PID i njihovih roditelja. Kontrolnu grupu obolelih sačinjavalo je 50 bolesnika sa juvenilnim idiopatskim artritisom (JIA) i 89 zdrave dece i njihovih roditelja. Kao instrument istraţivanja korišćen je pedijatrijski upitnik o kvalitetu ţivota (eng. Pediatric Quality of Life InventoryTM version 4.0, PedsQLTM), upitnik za pretragu anksioznosti (eng. Screen for Child Anxiety Related Emotional Disorders Questionnaire, SCARED), upitnik za pretragu raspoloţenja i osećanja (Mood and Feeling Questionnaire, MFQ), svi sa proverenim psihometrijskim karakteristikama. Rezultati: Bolesnici sa PID su imali lošiji ukupni skor kvaliteta ţivota u odnosu na bolesnike sa JIA i zdravu decu, i to kako na osnovu dečje samoprocene (p = 0,02) tako i na osnovu roditeljske procene (p < 0,001). Osim toga, deca sa PID su imala značajno lošije emocionalno funkcionisanje u odnosu na decu sa JIA i socijalno funkcionisanje u odnosu na obe grupe dece i to kako na osnovu samoprocene tako i na osnovu roditeljske procene. Deca sa PID se prema sopstvenoj proceni nisu razlikovala u pogledu školskog funkcionisanja u odnosu na druge dve grupe dece. MeĎutim, roditeljska procena je pokazala de su deca sa PID imala statistički signifikantno lošije školsko funkcionisanje u odnosu na decu sa JIA i zdravu decu. Prema roditeljskoj proceni, svako četvrto (24%) dete sa PID imalo je anksiozne simptome u klinički relevantnom opsegu, što je bilo statistički značajno više u odnosu na decu sa JIA i zdravu decu (p = 0,05). Osim toga, na osnovu dečje samoprocene, utvrĎeno je i da svako peto (20%) dete sa PID ima depresivne simptome u klinički relevantnom opsegu, što je ukazivalo na neophodnost ekspertske pomoći...sr
dc.description.abstractIntroduction: Health-related quality of life (HRQOL), as a multidimensional construct covering physical, emotional, mental, social, and behavioral components of well-being and functioning, has been recognized as one of the most important PRO measures for evaluating the outcome of a chronic pediatric condition. Considering that HRQOL data provides direct information about the impact of a disorder and its treatment, HRQOL assessments could be a part of multimodal assessment and treatment approach in children with primary immunodeficiency disease (PID) as well. Objective: The aims of the study were to evaluate levels of health-related quality of life (HRQOL) and the presence of anxiety and depressive symptoms in children with PID in Serbia. Methods: Self- and parent-rated data from 25 children with PID were available. As controls, data from 50 children with juvenile idiopathic arthritis (JIA) and 89 healthy children were included. The Pediatric Quality of Life Inventory (PedsQL) was used for HRQOL assessments. Anxiety symptoms were identified using the Screen for Child Anxiety Related Emotional Disorders Questionnaire (SCARED), while depressive symptoms were identified using the Mood and Feeling Questionnaire (MFQ). Results: Children with PID had significantly lower PedsQL total score compared to children with JIA and healthy children as child-rated (p = 0.02) and parent-rated (p < 0.001). Specifically, they had significantly lowered emotional functioning compared to children with JIA, and social functioning compared to both, children with JIA and healthy children. However, school functioning was significantly lower among children with PID as only parent-rated. As parent-rated, 6 (24%) out of 25 children with PID had significant anxiety symptoms, while 5 (20%) children had significant depressive symptoms, which was statistically higher than among children with JIA and healthy controls (p = 0.05). Conclusion: HRQOL could be significantly compromised in children with PID, particularly across psychosocial domains, such as emotional, social, and school. These children were also found to be at an increased risk for suffering significant anxiety and depressive symptoms...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectanksioznostsr
dc.subjectchildrenen
dc.subjectanxietyen
dc.subjectdepressionen
dc.subjectprimary immunodeficiency diseaseen
dc.subjectquality of lifeen
dc.subjectdepresivnostsr
dc.subjectprimarne imunodeficijencijesr
dc.subjectkvalitet ţivotasr
dc.titleProcena kvaliteta života kod dece i omladine sa primarnim imunodeficijencijamasr
dc.titleQuality of life assessment in children and adolescents with primary immunodeficienciesen
dc.typedoctoralThesis
dc.rights.licenseBY-NC
dcterms.abstractПашић, Срђан; Пантовић, Весна; Матејић, Бојана; Пекмезовић, Татјана; Кубуровић, Нина Б.; Процена квалитета живота код деце и омладине са примарним имунодефицијенцијама; Процена квалитета живота код деце и омладине са примарним имунодефицијенцијама;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/10209/Disertacija.pdf


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