Prediktivna vrednost demografskih i kliničkih karakteristika bolesnika operisanih od karcinoma želuca na rizik za nastanak recidiva i ukupno preživljavanje
Predictive value of demographic and clinical characteristics of patients, who had radical surgery because of gastric cancer, on risk for disease recidivism and overall survival
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Uvod Karcinom želuca i dalje predstavlja jedan od najznačajnijih javno-zdravstvenih
problema širom sveta. Radikalna operacija je i dalje jedini kurativni vid lečenja, ali
petogodišnje preživljavanje kod operisanih bolesnika je i dalje je vrlo loše pre svega zbog
loko-regionalnih recidiva. Više studija pokazalo je da postoperativna hemioterapija
donosi korist u ukupnom preživljavanju u odnosu na bolesnike koji su samo operisani.
Cilj rada Cilj ove studije bio je da se analizira uticaj demografskih i kliničkih
karakteristika kod pacijenata koji su imali kurativnu operaciju zbog karcinoma želuca, a
koji su nakon operacije podeljeni u dve grupe, grupu koja je samo praćena i grupu koja je
lečena adjuvantnom hemioterapijom po protokolu sa 5-fluorouracilom ( 5-FU).Navedena
adjuvantna terapija je inače standard u Srbiji , a i u regionu jugoistocne Evrope
Metod rada U ovo ispitivanje uključeno 115 osoba koje boluju od karcinoma želuca.
Kriterijumi za uključivanje bili su histopatološ...
Introduction Gastric cancer (GC) is even nowadays one of the most significant public
health problem all over the world. Radical surgery is the only way for curative treatment
but overall survival (OS) in patients who undergone surgery is still poor because of high
rate of local and regional recidivism. Several studies showed that postoperative
chemotherapy benefits to overall survival relative to patients who undergone surgery
only.
Purpose The aim of the study was to evaluate effects of demographic and clinical
characteristics in patients with gastric cancer who undergone curative surgery, after
surgery they were divided into two groups. One group was just followed and another
group was treated with adjuvant chemotherapy, applied protocol was one with 5-
fluoruracil (5-FU). This adjuvant chemotherapy (ACT) treatment is standard used in
Serbia, but also in region of Southeastern Europe.
Methods One hundred and fifteen patients with gastric cancer were enrolled in the study....