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Prognostic factors in the endoscopic treatment of sinonasal polyposis

dc.contributor.advisorĐukić, Vojko
dc.contributor.otherJanošević, Ljiljana
dc.contributor.otherMikić, Anton
dc.contributor.otherKosanović, Rade
dc.creatorDudvarski, Zoran R.
dc.date.accessioned2016-01-05T12:06:01Z
dc.date.available2016-01-05T12:06:01Z
dc.date.available2020-07-03T08:57:00Z
dc.date.issued2013-11-13
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=1067
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/2404
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:7761/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=44888847
dc.description.abstractUvod: Nosno-sinusna polipoza je hronično inflamatorno oboljenje sluznice nosa i paranazalnih sinusa koje dovodi do nastanka polipoidnih formacija u šupljini nosa. Smatra se podgrupom hroničnog rinosinuzitisa, a često se javlja u sklopu različitih oboljenja kao što su astma, intolerancija aspirina i cistična fibroza. Ranija istraživanja su pokazala da je prisustvo polipa u nosu povezano sa težom formom bolesti. Prema novijim istraživanjima, nosno-sinusna polipoza može dovesti do značajnih ograničenja u fizičkim, emocionalnim i socijalnim aspektima života obolelih. Stoga, osim kliničkih merenja težine bolesti na osnovu intenziteta simptoma, nalaza endoskopije nosa i kompjuterizovane tomografije (CT) paranazalnih sinusa, važan dodatni aspekt u globalnoj evaluaciji bolesnika predstavlja merenje kvaliteta života u vezi sa zdravljem. Neuspeh medikamentoznog tretmana u lečenju nosno-sinusne polipoze zahteva hirurško lečenje. Stopa uspešnosti funkcionalne endoskopske sinusne hirurgije (FESS) u lečenju hroničnog rinosinuzitisa i polipoze nosa je prema podacima iz literature 76-97,5%. Posle hirurškog lečenja 2,5-24% bolesnika i dalje ima simptome. Neuspeh u hirurškom lečenju se obično pripisuje anatomskim abnormalnostima, alergiji, astmi, recidivu polipoze, intoleranciji aspirina, cilijarnoj disfunkciji i drugim sistemskim oboljenjima. Iz navedenih razloga, jedan od glavnih ciljeva u novijim istraživanjima predstavlja pronalaženje potencijalnih prognostičkih faktora za rezultate hirurškog lečenja. Cilj: Proceniti terapijski efekat FESS-a u lečenju bolesnika sa nosno-sinusnom polipozom i ispitati prognostički značaj pojedinih faktora i komorbiditeta za rezultate lečenja. Materijal i metode: Ovom prospektivnom studijom je obuhvaćeno 85 bolesnika sa nosno-sinusnom polipozom (≥18 godina) koji su lečeni endoskopskom sinusnom hirurgijom posle neuspeha medikamentoznog tretmana. Simptome bolesnika smo grupisali kao major i minor faktore, a njihov intenzitet je prikazan pomoću vizuelne analogne skale (VAS). Kvalitet života je prikazan pomoću generičkog upitnika SF-36. Objektivni status bolesnika je prikazan kao endoskopski i CT skor. Bolesnici su evaluirani u okviru cele grupe i odgovarajućih podgrupa, koristeći demografske faktore, kliničke faktore i komorbiditete kao dihotomne varijable (pol, godine života, prethodno hirurško lečenje, alergija, astma, intolerancija aspirina)...sr
dc.description.abstractIntroduction: Sino-nasal polyposis is a chronic inflammatory disease of the mucous membrane of the nose and paranasal sinuses, which leads to the forming of polypoid formations inside the nasal cavity. It is considered to be a subgroup of chronic rhinosinusitis, and it often appears related to variuos diseases such as asthma, intolerance to aspirin and cystic fibrosis. Earlier research indicated that the presence of polyps in the nose is related to a more serious form of disease. According to later research sino-nasal polyposis can lead to significant limitations regarding physical, emotional and social aspects of patients’ lives. Therefore, besides clinical evaluation of the seriousness of disease based on the intensity of symptoms, nasal endoscopy findings and computerized tomography (CT) of paranasal sinuses, the important additional aspect in the global evaluation of a patient is the evaluation of the quality of life regarding health. The failure of medicamentous treatment of sino-nasal polyposis requires surgical treatment. The success rate of functional endoscopic sinus surgery (FESS) in treatment of chronic rhinosinusitis and nasal polyposis, according to literature data, is 76-97,5%. After surgical treatment 2,5-24% patiens continue to have symptoms. The failure of surgical treatment is usually ascribed to anatomical abnormalities, allergy, asthma, recurrency of polyposis, intolerance to aspirin, ciliary dysfunction and other system diseases. Due to aforementioned reasons, one of the primary goals in the recent research is discovering the potential prognostic factors for the outcome of surgical treatment. Outcomes: The evaluation of therapeutic effect of FESS in the treatment of patients with sino-nasal polyposis and the examining of prognostic significance of certain factors and comorbidities for the outcomes of treatment. Material and methods: This prospective study has comprised 85 patients with sinonasal polyposis (age ≥18) who were treated by endoscopic sinus surgery after the failure of medicamentous treatment. We have grouped the patients’ symptoms into major and minor factors, and their intensity is presented by means of visual analogous scale (VAS). The quality of life is presented by general health survey SF-36. The objective status of patients is presented as endoscopic and CT score...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectNosno-sinusna polipozasr
dc.subjectSino-nasal polyposisen
dc.subjectfunkcionalna endoskopska hirurgija sinusasr
dc.subjectkliničke karakteristikesr
dc.subjectkvalitet životasr
dc.subjectprognostički faktorisr
dc.subjectfunctional endoscopic sinus surgeryen
dc.subjectclinical characteristicsen
dc.subjectquality of lifeen
dc.subjectprognostic factorsen
dc.titlePrognostički faktori u endoskopskom lečenju nosno-sinusne polipozesr
dc.titlePrognostic factors in the endoscopic treatment of sinonasal polyposisen
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dcterms.abstractЂукић, Војко; Косановић, Раде; Јаношевић, Љиљана; Микић, Aнтон; Дудварски, Зоран Р.; Прогностички фактори у ендоскопском лечењу носно-синусне полипозе; Прогностички фактори у ендоскопском лечењу носно-синусне полипозе;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/12049/Disertacija.pdf


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