Istraživanje i razvoj gaspropusnih nanofotonskih kontaktnih sočiva na bazi polimetilakrilata i fulerena
Research and development of gas permeable nanophotonic contact lenses based on polymethylacrylate and fullerene.
Author
Stamenković, DragomirMentor
Koruga, ĐuroCommittee members
Vasić, Aleksandra
Bojović, Božica

Stankov, Branko
Jakšić, Vesna

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Show full item recordAbstract
Predmet ove disertacije je istraživanje, razvoj i karakterizacija nove vrste
materijala za proizvodnju gaspropusnih (RGP) kontaktnih sociva na bazi modifikovanog
polimetilakrilata (PMA) i adiranih fulerena, tj. njihovih modifikovanih formi
polimetilmetakrilata (PMMA), fulerola i metforminom hidrogenizovanih fulerena. Na
osnovu uocenih problema u primeni kontaktnih sociva u klinickoj praksi pristupilo se
istraživanju i razvoju nove vrste materijala za proizvodnju gaspropusnih kontaktnih sociva,
vodeci racuna o zahtevima koje moraju da ispune medicinska pomagala za korekciju vida.
Uspešno je obavljena polimerizacija i na bazi osnovnog klasicnog gaspropusnog materijala
Soleko SP40TM, ukljucivanjem cestica fulerena u njegovu polimernu strukturu, proizvedeni
su uzorci novih nanofotonskih materijala: SP40+C60, SP40+C60(OH)24 i
SP40+C60(OH)12(OC4N5H10)12. Proizvodnja nanofotonskih kontaktnih sociva od
novodobijenih materijala obavljena je metodom rezanja na troosnom toricnom CNC strugu
novije... generacije. Za karakterizaciju materijala i gotovih kontaktnih sociva korišcene su
nanotehnološke metode: mikroskopija atomskih sila (AFM), mikroskopija magnetnih sila
(MFM), opto-magnetna spektroskopija (OMS), kao i UV-VIS, NIR i FTIR spektroskopija.
Ispitivanja su pokazala da su opticke i mehanicke karakteristike nanofotonskih materijala
kao što su: indeks prelamanja, propustljivost za kiseonik i tvrdoca, zadovoljavajuce, a da su
znacajno poboljšane osobine: transmitivnost talasnih dužina vidljivog spektra u skladu sa
spektralnom efikasnošcu oka, zaštita od ultraljubicastog zracenja, kvašljivost i kvalitet
obradenih površina. Preliminarna ispitivana biokompatibilnosti pokazuju da nanofotonski
materijali nisu citotoksicni. Dobijeni rezultati su prakticno primenljivi i na osnovu njih je
moguc razvoj nove generacije materijala za gaspropusna i ostala kontaktna sociva.
The aim of the dissertation is to investigate, develop and characterize new
material for production of rigid gas permeable (RGP) contact lenses. The new RGP
material is based on adding fullerenes to modify poly-methylacrylate (PMA), i.e. it’s
modified forms: poly-methyl-methacrylate (PMMA), fullerene hydroxylate and fullerene
metformin hydroxylate. The development and investigation of new materials for RGP
contact lens production was done based on the existing problems in the everyday medical
application of contact lenses. In doing this, all the administrative requirements for the usage
of optical vision correction medical devices were fulfilled. Oxidative polymerization of
classical RGP material, Soleko SP40TM was successfully carried out with the addition of
fullerene particles in its polymeric structure. This is how a new “nano-photonic” material
has been produced: SP40+C60, SP40+C60(OH)24 i SP40+C60(OH)12(OC4N5H10)12.
Production of nano-photonic contact lenses out of newly synthesi...zed material was carried
out using lathe cut method on a new generation toric 3-axes CNC lathe. For the purposes of
RGP material and contact lens characterization, nano-technology methods were used
(Atomic Force Microscopy (AFM), Magnetic Force Microscopy (MFM), Optomagnetic
Spectroscopy (OMS)), as well as spectroscopy methods (UV-VIS, NIR and FTIR). The
results of the investigation have shown that the optical and mechanical properties of the
new RGP nano-photonic material such as: refractive index, oxygen permeability and
modulus of elasticity are similar to the classical RGP material, while some other, such us:
visible light transmittance, UV block, wettability and the lathe cut surface quality, are
significantly improved. Preliminary tests suggest that newly developed RGP nano-photonic
RGP material is biocompatible. The facts gotten from the investigation can be applied in
future investigation in this field and there is a clear possibility that these can be used for the
purposes of developing a new generation of materials for rigid gas permeable and other
contact lenses.