Farmakognozijsko ispitivanje podzemnih organa srpske velistike Ferula heuffelii Griseb. ex Heuffel (Apiaceae)
Pharmacognostic investigation of underground parts of Ferula heuffelii Griseb. ex Heuffel (Apiaceae)
Author
Pavlović, Ivan N.Mentor
Petrović, Silvana
Committee members
Radenković, MirjanaMilenković, Marina

Metadata
Show full item recordAbstract
Predmet doktorske disertacije je analiza hemijskog sastava i ispitivanje
farmakološke aktivnosti izolata (etarskih ulja, hloroformskog i metanolnog ekstrakta i
metabolita) podzemnih organa srpske velestike, Ferula heuffelii Griseb. ex Heuffel
(Apiaceae). Srpska velestika je endemična vrsta koja naseljava klisure i stenovite terene
istočne Srbije, jugozapadne Rumunije i zapadne Bugarske. Ova vrsta do sada nije
ispitivana u pogledu hemijskog sastava i farmakološke aktivnosti.
Etarska ulja podzemnih organa F. heuffelii izolovana su iz uzoraka prikupljenih
na tri lokaliteta u Republici Srbiji: Sićevačkoj klisuri, Đerdapskoj klisuri i klisuri reke
Pek. Etarska ulja su izolovana destilacijom vodenom parom i hemijski okarakterisana
metodama GC-FID i GC-MS. Etarsko ulje izolovano iz podzemnih organa poreklom iz
Sićevačke klisure (F1) bilo je bogato seskviterpenima (48,7%) i fenilpropanima
(17,0%), a glavni sastojak bio je elemicin (12,5%). Etarska ulja izolovana iz podzemnih
organa prikupljeni...h u Đerdapskoj klisuri (F2) i klisuri reke Pek (F3), karakterisao je visok
sadržaj fenilpropanskih jedinjenja (56,0 i 29,7%, redom), pri čemu su elemicin (35,4 i
16,8%, redom) i miristicin (20,6 i 12,9%, redom), bili najzastupljenije komponente.
Razlike između ispitivanih etarskih ulja bile su pre svega kvantitativne prirode (...)
The scope of this doctoral dissertation represents chemical analysis of
underground parts of Ferula heuffelii Griseb. ex Heuffel (Apiaceae), and investigation of
pharmacological activity of its isolates (chloroform and methanol extracts, essential oils
and metabolites). Ferula heuffelii („srpska velestika“) is an endemic and rare perennial
species which grows predominantly in gorges and stony places in Eastern Serbia, and
locally in Southwestern Romania and Western Bulgaria. This plant has not been
previously investigated for chemical composition and pharmacological activity.
The essential oils of underground parts of F. heuffelii were isolated from the
samples collected from three localities in Serbia: the Sićevo Gorge; the Djerdap Gorge
and the gorge of the river Pek. The oils were isolated by hydrodistillation in a
Clevenger-type apparatus and analyzed by GC-FID and GC-MS methods. The oil from
underground parts obtained from the Sićevo gorge (F1) was rich in sesquiterpene
hydrocarbo...ns (48.7%) and phenylpropanoids (17%), and elemicin was the major
constituent (12.5%). The oils isolated from underground parts collected in the Djerdap
gorge (F2) and in the gorge of the river Pek (F3), were characterized by high content of
phenylpropanoids (56.0 and 29.7%, respectively), with elemicin (35.4 and 16,8%,
respectively) and myristicin (20.6 and 12,9%, respectively) being the main compounds.
The differences in chemical composition between the essential oils were mainly
quantitative (...)