Analiza i upoređenje kvaliteta života bolesnika sa nemetastatskim karcinomom prostate koji su lečeni radikalnom prostatektomijom i hormonoterapijom
Author
Dinić, LjubomirMentor
Bašić, DragoslavCommittee members
Ignjatović, IvanAleksić, Predrag
Đorđević, Nebojša
Veljković, Andrej
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Show full item recordAbstract
The aim of the study was to evaluate health-related quality of life in
patients with non-metastatic prostate cancer. The patients were divided in
two groups. The first group consisted of patients who underwent RRP, and
the second group consisted of those who were primarily treated with
hormonal therapy for 12 months and then underwent external radiation
therapy (H + Z). The (EPIC) questionnaire was used to evaluate healthrelated
quality of life (HRQoL), the (IIEF-SF) questionnaire was used to
assess erectile function, the (ICIQ-UI) questionnaire was used to assess
urinary incontinence, and IPSS questionnaire was used to assess lower
urinary tract symptoms. All patients filled out questionnaires before the
start of treatment, in the 3rd, 6th, 12th, 15th, 18th and 24th months of followup.
At 12-month follow-up compared to baseline, the greatest decrease in
mean IIEF score (p < 0.05), the greatest increase in mean ICIQ-UI score
(p < 0.01), the greatest decrease in the mean IPSS score (p <... 0.001), and
the greatest decrease in IPSS QoL score (p < 0.001) was in RRP group. For
HRQoL, according to the EPIC results, urinary function, urinary
incontinence and sexual function significantly decreased compared to
baseline after 12 months (p < 0.05 for all) in RRP group, and hormonal
function, sexual function and sexual bother (p < 0.001 for all) in the (H +
Z) group. From 12th to 24th months in the RRP group, there were no
changes in the mean IIEF, ICIQ-UI, IPSS, IPSS QoL scores compared to
the 12th month, nor in the HRQoL results. In the H + Z group, a significant
decrease in the IIEF score, a decrease in sexual function and sexual bother,
and an increase in hormonal function were verified. From a HRQoL
perspective, both treatment modalities can offer satisfactory functional
outcomes. RRP has the greatest impact on urinary and sexual function,
hormonal therapy on sexual and hormonal function, and H + Z on sexual
function and sexual bother.