Uticaj kvaliteta metaboličke kontrole na ishod lečenja fizikalnim procedurama bolesnika sa gonartrozom i dijabetes melitusom tip 2
The influence of the quality of metabolic control on the outcome of treatment with physical procedures of patients with gonarthrosis and type 2 diabetes melitus
Докторанд
Milošević, JelenaМентор
Jurišić-Škevin, AleksandraЧланови комисије
Simanić, IgorĐukić, Aleksandar
Lazović, Milica
Метаподаци
Приказ свих података о дисертацијиСажетак
UVOD: Gonartroza i DM tip 2 su dve bolesti koje sve češće koegzistiraju, što zbog velike
prevalencije, što zbog brojnih zajedničkih faktora rizika. Primena fizikalne terapije
zauzima značajno mesto u lečenju kako pacijenata sa gonartrozom, tako i pacijenata sa DM
tip 2. Magnetoterapija i kineziterapija su agensi koji se najčešće koriste za lečenje
pacijenata sa gonartrozom.
CILj: Osnovni cilj ovog rada bio je da se ispita uticaj DM tip 2 na ishod lečenja
fizikalnom terapijom pacijenata sa gonartrozom.
METODE: Eksperimentalna studija kojom je obuhvaćeno 66 pacijenata, podeljeni u dve
grupe u odnosu na prisustvo DM tip 2. Eksperimentalnu grupu su činili pacijenti sa
gonartrozom i DM tip 2, a kontrolnu grupu pacijenti sa gonartrozom. Tokom analize
podataka eksperimentalna grupa je podeljena na pacijente sa gonartrozom i regulisanim
DM tip 2 i grupu sa gonartrozom i neregulisanim DM tip 2. Varijable praćene u
istraživanju su biohemijski parametri, citokini (TNF-α, IL-6, IL-17, IL...-10, INF-γ, IL-12,
IL-23, TGF-β, IL-33, Gal-3)), WOMAC upitnik, Mc-Gill upitnik, VAS skala, EQ5D upitnik,
Lequesne indeks, test monofilamenta, MNSI, NSS, NDS, MMT, merenje obima pokreta u
zglobu.
REZULTATI: Rezultati pokazuju da fizikalna terapija ima pozitivan efekat kod
pacijenata sa gonartrozom i DM tip 2, kao i kod pacijenta sa gonartrozom, mereno kroz
skor WOMAC indeksa. DM tip 2 ima negativan efekat na fizikalnu terapiju kod
pacijenata sa gonartrozom.
ZAKLjUČAK: Na osnovu dobijenih rezultata možemo zaključiti da loša glikoregulacija
može imati negativan uticaj na ishod lečenja fizikalnom terpijom pacijenta sa
gonartrozom.
INTRODUCTION: Gonarthrosis and DM type 2 are two diseases that coexist more and more
often, due to their high prevalence and due to numerous common risk factors. The application of
physical therapy occupies an important place in the treatment of both patients with gonarthrosis
and patients with DM type 2. Magnetotherapy and kinesitherapy are the agents most often used to
treat patients with gonarthrosis.
AIM: The main goal of this work was to examine the impact of DM type 2 on the outcome of
physical therapy treatment of patients with gonarthrosis.
METHODS: An experimental study that included 66 patients, divided into two groups in relation
to the presence of DM type 2. The experimental group consisted of patients with gonarthrosis and
DM type 2, and the control group consisted of patients with gonarthrosis. During data analysis, the
experimental group was divided into patients with gonarthrosis and regulated DM type 2 and a
group with gonarthrosis and unregulated DM type 2. T...he variables monitored in the study were
biochemical parameters, cytokines (TNF-α, IL-6, IL-17, IL-10, INF-γ, IL-12, IL-23, TGF-β, IL-33,
Gal-3)), WOMAC questionnaire, Mc-Gill questionnaire, VAS scale, EQ5D questionnaire, Lequesne
index, monofilament test, MNSI, NSS, NDS, MMT, wrist range of motion measurement.
THE RESULTS: The results show that physical therapy has a positive effect in patients with
gonarthrosis and DM type 2, as well as in patients with gonarthrosis, as measured by the WOMAC
index score. DM type 2 has a negative effect on physical therapy in patients with gonarthrosis.
CONSLUSION: Based on the obtained results, we can conclude that poor glycoregulation can
have a negative impact on the outcome of physical therapy treatment of a patient with gonarthrosis