Приказ основних података о дисертацији

dc.contributor.advisorVasiljević, Perica
dc.contributor.otherNajman, Stevo
dc.contributor.otherĐorđević, Ljubiša
dc.contributor.otherJušković, Marina
dc.contributor.otherStojanović, Gordana
dc.creatorMadić, Višnja
dc.date2020
dc.date.accessioned2022-12-05T13:22:07Z
dc.date.available2022-12-05T13:22:07Z
dc.date.issued2021-03-03
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=8542
dc.identifier.urihttps://fedorani.ni.ac.rs/fedora/get/o:1810/bdef:Content/download
dc.identifier.urihttps://plus.cobiss.net/cobiss/sr/sr/bib/34727689
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/21028
dc.description.abstractDiabetes is one of the most prevalent diseases of the 21st century. Conventional pharmacotherapy of diabetes successfully regulates hyperglycemia, yet it cannot completely prevent the progress of secondary diabetic pathologies. Thus, many people combine pharmacotherapy with herbal remedies. This study aimed to evaluate the frequency of traditional medicine use in Serbia and to examine the biological activities of the “anti-diabetic” herbal mixture used in the ethnopharmacology. The prevalence of traditional medicine use was assessed by cross-sectional study, while the biological activities of the herbal mixture were examined through in vitro and in vivo experiments. The results of the study showed that 67.7% of respondents from all over Serbia rely on ethnopharmacology. The consumption of polyherbal mixtures and pharmaceutical supplements based on traditional recipes was more frequent than individual medicinal herbs. Phytochemical analysis of tested herbal mixture indicated high content of phenols and flavonoids. The HPLC-UV analysis revealed the presence of ten bioactive compounds: quinic, gallic and caftaric acid, arbutin, rutin, trifolin, astragalin, hyperoside, isoquercetin and quercitrin. In vitro study indicated its high antioxidant, anticytotoxic and antigenotoxic activities as well as antimicrobial activity against a wide range of microorganisms. In addition, its cytotoxicity and genotoxicity were extremely low. In vivo study showed that this herbal mixture has hypoglycemic, hypolipidemic and hepatoprotective effects in both healthy and diabetic animals. Moreover, in diabetic animals, it showed nephroprotective activity, while its hypoglycemic effect was higher than the effect of insulin and metformin in this experimental model.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Природно-математички факултетsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Нишуsr
dc.subjectDijabetessr
dc.subjectDiabetesen
dc.subjectbiljna mešavinasr
dc.subjectnarodna medicinasr
dc.subjectcitotoksičnostsr
dc.subjectgenotoksičnostsr
dc.subjectantioksidansisr
dc.subjecthipoglikemijski agensisr
dc.subjecthepatoprotektivni efekatsr
dc.subjectnefroprotektivni efekatsr
dc.subjecthipolipidemijsko dejstvosr
dc.subjectherbal mixtureen
dc.subjecttraditional medicineen
dc.subjectcytotoxicityen
dc.subjectgenotoxicityen
dc.subjectantioxidantsen
dc.subjecthypoglycemic agentsen
dc.subjecthepatoprotective effecten
dc.subjectnephroprotective effecten
dc.subjecthypolipidemic activityen
dc.titleProcena biološke aktivnosti biljne mešavine koja se primenjuje u etnofarmakološkom tretmanu dijabetesasr
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/148427/Doctoral_thesis_12939.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/148426/Madic_Visnja_P.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_21028


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Приказ основних података о дисертацији