Prognostički značaj vrednosti homocisteina, folne kiseline i vitamina V12 u krvi obolelih od malignih tumora mozga
Prognostic significance of homocysteine, folic acid and vitamin B12 in the blood of patients with malignant brain tumorsrats
Doktorand
Đurović, ŽivankaMentor
Živković, VladimirČlanovi komisije
Jakovljević, VladimirKovačević, Vojin
Ilić, Tihomir
Metapodaci
Prikaz svih podataka o disertacijiSažetak
Uvod: Poslednjih godina se sve više ukazuje na moguće efekte homocisteina i
jedinjenja uključenih u njegov metabolizam u karcinomima nervnog tkiva. U tom
smislu, može se uočiti da je efekat homocisteina, folne kiseline i vitamina V12 na
formiranje, razvoj i ishod lečenja kod pacijenata sa karcinomima mozga veoma
intrigantno pitanje, čiji odgovor zahteva dodatno eksperimentalno i kliničko
istraživanje. U literaturi nema dovoljno podataka o učestalosti povišenih nivoa
Hcy u krvi, kao ni o poremećajima folne kiseline i vitamina B12 kod malignih
tumora mozga.
Cilj: Generalni cilj ove studije je bio da utvrdi prognostički značaj vrednosti
homocisteina, folne kiseline i vitamina V12 u krvi kod pacijenata adultne
populacije sa malignim tumorima mozga.
Metode: Studijom je bilo obuhvaćeno 100 ispitanika oba pola koji su u periodu od 24
meseca bili praćeni i hirurški lečeni od malignih i benignih neurohirurških
patoanatomskih supstrata na Neurohirurškoj klinici Kliničkog centra Srbije.
Mesec dan...a, tri meseca i šest meseci nakon operacije kod ispitanika i sa malignim
i benignim tumorom sakupljani su uzorci krvi radi određivanja koncentracije
sledećih parametara: ukupni homocistein, vitamin B12 i folna kiselina; rutinske
biohemijske analize (krvna slika, lipidni profil, hepatogram, urea i kreatinin);
markera inflamacije (C-reaktivni protein, fibrinogen, prokalcitonin).
Rezultati: Koncentracija homocisteina bila je značajno veća kod pacijenata kod
kojih je bolest uznapredovala u poređenju sa pacijentima kod kojih bolest nije
uznapredovala, čak i šest meseci nakon hirurškog odstranjivanja tumora, ali
ostajući u fiziološkim granicama. Ovo potencijalno znači da se merenje vrednosti
homocisteina može eventualno razmotriti kao marker progresije malignih oboljenja
mozga. Potrebna su dalja i kompleksnija istraživanja na većem broju ispitanika kako
bi se svi prethodno izneti zaključci potvrdili i time povećala relevantnost i
klinička primenjivost naših rezultata.
Introduction: The use of mineral waters for medicаl purposes is largely based on theoretical
assumptions (which take into account the relationship between their mineral composition and
pathophysiological substrate within a disease) and much less on relevant data from basic and
clinical research. Most of the data that indicate that certain types of these waters can alleviate
the progression of various diseases and even be associated with complete remission come
from non-academic and scientifically unfounded sources. In addition, the mechanisms by
which these positive effects are realized are almost unknown.
Objective: The overall aim of this study was to determine the prognostic significance of
homocysteine, folic acid and vitamin B12 levels in the blood of adult patients with malignant
brain tumors.
Methods: The study included 100 subjects of both genders who were followed and surgically
treated for malignant and benign neurosurgical pathoanatomical substrates at the
Neurosurgical Clin...ic of the Clinical Center of Serbia for a period of 24 months. One month,
three months, and six months after surgery, blood samples were collected from subjects with
both malignant and benign tumors to determine the concentration of the following
parameters: total homocysteine, vitamin B12, and folic acid; routine biochemical analyzes
(blood count, lipid profile, hepatogram, urea and creatinine); markers of inflammation (Creactive protein, fibrinogen, procalcitonin).
Results: Homocysteine concentrations were significantly higher in patients in whom the
disease progressed compared to patients in whom the disease did not progress, even six
months after surgical removal of the tumor, but remaining within physiological limits. This
potentially means that measuring homocysteine levels can potentially be considered as a
marker of the progression of malignant brain diseases. Further and more complex research is
needed on a larger number of respondents in order to confirm all the previously presented
conclusions and thus increase the relevance and clinical applicability of our results.