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Effect of dietary restriction on meuronal and glial plasticity following injury to the rat somatosensory cortex

dc.contributor.advisorKanazir, Selma
dc.contributor.otherNedeljković, Nadežda
dc.contributor.otherPešić, Vesna
dc.contributor.otherRuždijić, Sabera
dc.contributor.otherPerović, Milka
dc.creatorLončarević-Vasiljković, Nataša
dc.date.accessioned2016-01-05T11:45:33Z
dc.date.available2016-01-05T11:45:33Z
dc.date.available2020-07-03T08:08:29Z
dc.date.issued2012-09-28
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/2042
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=39
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:2348/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=41539855
dc.description.abstractTraumatska povreda mozga (engl. traumatic brain injury, TBI) predstavlja povredu moždanog tkiva uzrokovanu mehaničkom povredom glave. TBI je jedan od vodećih uzroka smrtnosti i invaliditeta u svetu, u populaciji ljudi do 45 godina starosti. Posledice TBI zavise od lokalizacije i količine oštećenja moždanog tkiva i mogu varirati od blažih motoričkih i kognitivnih smetnji, pa sve do težih oblika invaliditeta i smrti. Traumatska povreda mozga dovodi do narušavanja krvno-moždane barijere, što rezultuje tačno određenim sledom događaja u povređenom tkivu CNS-a. Naime, akutna faza, označena kao primarna povreda, nastaje direktnim delovanjem mehaničke sile na moždano tkivo i javlja se u trenutku povrede. Događaji koji slede nakon toga označeni su kao sekundarna povreda koja nastaje kao posledica inicijalnog oštećenja, a obuhvata procese koji dovode do daljeg oštećenja tkiva u danima i nedeljama nakon povrede. To su pre svega zapaljenski procesi koji dovode do smrti neurona koji prvobitno nisu bili zahvaćeni mehaničkom povredom. Smatra se da je broj neurona koji umre usled širenja sekundarne povrede daleko veći od broja neurona koji strada usled primarne povrede. Činjenica da se većina procesa u okviru sekundarne povrede odigrava relativno kasno (satima i danima nakon povrede) čini ih podložnim različitim terapeutskim intervencijama. Već decenijama je poznato da restrikcija hrane povoljno deluje na čitav organizam tako što odlaže starosno-zavisne fiziološke promene i smanjuje incidencu različitih obolenja (kancer, autoimunske bolesti, Parkinsonova i Alchajmerova bolest, itd.) Međutim, tek u poslednjih desetak godina intenzivno se istražuje uticaj smanjenog unosa hrane na procese oporavka nakon povrede. Dosadašnja istraživanja na ovom polju su pokazala da restrikcija hrane u trajanju od nekoliko meseci pre povrede CNS-a ima neuroprotektivno dejstvo i promoviše funkcionalni oporavak u nekoliko različitih modela povrede...sr
dc.description.abstractTraumatic brain injury (TBI) represents a brain tissue injury caused by mechanical head injury. TBI is one of the leading causes of death and disability in the world human population, up to 45 years of age. Consequences of brain injury depend on the location and amount of brain tissue damage, and can range from mild motor and cognitive impairment, to severe forms of disability and death. Traumatic brain injury leads to impairment of blood-brain barrier, resulting in a precisely defined sequence of events in injured CNS tissue. Two main phases could be distinguished: acute phase, which is called the primary injury that occurs by direct action of mechanical forces on the brain tissue and occurs at the time of injury. The events that followed thereafter are called the secondary injury. Secondary injury occurs as a result of the initial damage, and includes the processes that lead to further tissue damage in the days and weeks following injury. These are primarily inflammatory processes that lead to the death of neurons that initially were not affected by mechanical injury. It is believed that the neuronal cell death caused by secondary injury is far greater than the one caused by primary injury. The fact that most of the processes within the secondary injury occur relatively late (hours and days following injury) makes them subject to various therapeutic interventions. For decades, it is known that food restriction has a beneficial effect on the entire organism by delaying age-dependent physiological changes and reducing the incidence of various diseases (cancer, autoimmune disease, Parkinson's and Alzheimer's, etc). However, only in the last ten years has been to investigate the influence reduced food intake in the recovery process following injury. Previous research in this field has shown that several months long food restriction prior to CNS injury has neuroprotective effects and promotes functional recovery in several different models of injury...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Биолошки факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173056/RS//
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectPovreda mozgasr
dc.subjectBrain injuryen
dc.subjectmoždana korasr
dc.subjectdijetalna restrikcijasr
dc.subjectpacovsr
dc.subjectcerebral cortexen
dc.subjectdietary restrictionen
dc.subjectraten
dc.titleUticaj restriktivnog režima ishrane na plastičnost neurona i glije nakon povrede senzomotorne kore mozga pacovasr
dc.titleEffect of dietary restriction on meuronal and glial plasticity following injury to the rat somatosensory cortexen
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dcterms.abstractКаназир, Селма; Недељковић, Надежда; Руждијић, Сабера; Перовић, Милка; Пешић, Весна; Лончаревић-Васиљковић, Наташа; Утицај рестриктивног режима исхране на пластичност неурона и глије након повреде сензомоторне коре мозга пацова; Утицај рестриктивног режима исхране на пластичност неурона и глије након повреде сензомоторне коре мозга пацова;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/1894/Disertacija.pdf


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