Diverzitet peptidnih sekvenci u amiloidnom agregiranju proteina

Milošević, Jelica

Diversity of peptide sequences in amyloid aggregation of proteins

Abstract

Kako proteinski biomakromolekuli imaju složenu, ali metastabilnu trodimenzionalnu strukturu, podložni su agregiranju pri različitim promenama uslova okoline. Agregati se odlikuju različitim stepenom uređenosti, od potpuno amorfnih do visoko uređenih amiloidnih fibrila...

Biological macromolecules have complex, but metastable 3D structures. Upon conformational changes in different conditions, they are prone to aggregation. Protein aggregates have various organizations, from completely unordered to highly ordered amyloid fibrils...

Faculty:
University of Belgrade, Faculty of Chemistry
Date:
09-07-2021

Keywords:

amiloidni fibrili, oligomeri, agregaciona β-pločica, FTIR spektroskopija, agregiranje, polipeptidi, proteinske sekvence, heterogene smeše proteina, izoforme ficina / amyloid fibrils, oligomers, aggregation β-sheet, FTIR spectroscopy, aggregation, polypeptides, protein sequences, heterogeneous protein mixture, ficin isoforms.

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