Uticaj materijala za dentalne ispune aproksimalnih preparacija na parametre oksidativnog stresa u gingivalnoj sulkusnoj tečnosti
Influence of dental materials for fillings of proximal preparations on oxidative stress parameters in gingival crevicular fluid
Author
Taso, ErvinMentor
Kanjevac, Tatjana
Committee members
Milovanović, MarijaZelen, Ivanka

Vojvodić, Danilo

Metadata
Show full item recordAbstract
Sažetak: Biokompatibilnost dentalnih materijala (DRMs) može se proceniti
ispitivanjem statusa oksidativnog stresa (OS) gingivalne crevikularne tečnosti
(GCF).
Cilj ove studije bio je da se utvrdi uticaj stepena dentalnog karijesa, pozicije zuba,
tipa i količine primenjenog restorativnog materijala (DRMs) na OS profil u GCF. U
tu svrhu ispitivano je šest restorativnih materijala DRMs koji su korišćeni u
tretmanu: amalgam (Amg), kompoziti: TetricEvoCeram (TEC) i Beautifil (BF), fosfatni
cement - cink-fosfat (ZPhC) i polikarboksilatni cementi - cink polikarboksilatni
cementi (ZpoC) i glas-jonomer cement (GIC).
Materijal i metode Studijom je obuhvaćeno 88 ispitanika. Osim na početku (0-ti
dan), ispitanici su kontrolisani 7-og i 30-tog dana. Parametri oksidativnog stresa
nivoi malondialdehida (MDA) i glutationa (GSH) i ukupna aktivnost superoksid
dismutaze (tSOD) su mereni pre (0-ti dan) i posle tretmana (7 i 30-tog dana) u GCF.
Kontrolni zdravi zubi su pozicionirani kao odraz ...u ogledalu.
Rezultati: Dentalni karijes inicira neznatan porast OS u GCF. Primena različitih
restorativnih materijala dovela je do sledećih efekata (efekti se smanjuju po
navedenom redosledu): porast GSH u GCF: ZpoC>BF>GIC>Amg, porast aktivnosti
tSOD: ZpoC>BF>Amg; i smanjenje MDA: ZpoC>ZPhC>Amg >TEC. ZpoC i ZPhC su
pokazali najveći antioksidativni efekat, nasuprot GIC.
Zaključak: Restauracije sa materijalima koji imaju antioksidativna svojstva mogu da
redukuju bolesti desni inicirane karijesnom lezijom, što je od bitne kliničke
važnosti u stomatologiji.
Abstract: Biocompatibility of dental materials (DMs) can be evaluated by gingival
crevicular fluid (GCF) and oxidative stress (OS) status. The goal of the study was to ascertain
influence of dental caries degree, teeth position and type and amount of applied DM on GCF
OS profile. For this purpose we tested six DRMs that were used in one session: amalgam
(Amg), composites: TetricEvoCeram (TEC) and Beautifil (BF), phosphate cement - zinc
phosphate (ZPhC) and polycarboxylate cements - zinc polycarboxylate cements (ZpoC) and
glass ionomer cement (GIC).
Material and Methods: The study included 88 dental outpatients. Follow up was scheduled on
the 7th and 30th day. Oxidative stress parameters [malondialdehyde (MDA) and glutathione
(GSH) levels and total superoxide dismutase (tSOD]) activity were measured before (day zero)
and after the treatment (7th and 30th day) in GCF. Healthy control teeth were positioned as
reflection in the mirror.
Results: Dental caries provokes insignific...ant rise of OS in GCF. The DMs accomplished
following effects (listed in descending order): increase of GSH in GCF: ZPoC>BF>GIC>Amg;
tSOD activity increase: ZPoC>BF>Amg; and MDA decrease: ZPoC>ZPhC>Amg>TEC. ZPoC
and ZPhC showed the highest antioxidant effect, contrary to GIC.
Conclusion: Restorations with antioxidant properties may reduce gum diseases initiated by
caries lesion, which is of great clinical relevance in dentistry.