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Uticaj materijala za dentalne ispune aproksimalnih preparacija na parametre oksidativnog stresa u gingivalnoj sulkusnoj tečnosti

Influence of dental materials for fillings of proximal preparations on oxidative stress parameters in gingival crevicular fluid

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2021
Doctoral_thesis_12132.pdf (2.408Mb)
Ervin_Taso_referat.pdf (596.9Kb)
Author
Taso, Ervin
Mentor
Kanjevac, Tatjana
Committee members
Milovanović, Marija
Zelen, Ivanka
Vojvodić, Danilo
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Abstract
Sažetak: Biokompatibilnost dentalnih materijala (DRMs) može se proceniti ispitivanjem statusa oksidativnog stresa (OS) gingivalne crevikularne tečnosti (GCF). Cilj ove studije bio je da se utvrdi uticaj stepena dentalnog karijesa, pozicije zuba, tipa i količine primenjenog restorativnog materijala (DRMs) na OS profil u GCF. U tu svrhu ispitivano je šest restorativnih materijala DRMs koji su korišćeni u tretmanu: amalgam (Amg), kompoziti: TetricEvoCeram (TEC) i Beautifil (BF), fosfatni cement - cink-fosfat (ZPhC) i polikarboksilatni cementi - cink polikarboksilatni cementi (ZpoC) i glas-jonomer cement (GIC). Materijal i metode Studijom je obuhvaćeno 88 ispitanika. Osim na početku (0-ti dan), ispitanici su kontrolisani 7-og i 30-tog dana. Parametri oksidativnog stresa nivoi malondialdehida (MDA) i glutationa (GSH) i ukupna aktivnost superoksid dismutaze (tSOD) su mereni pre (0-ti dan) i posle tretmana (7 i 30-tog dana) u GCF. Kontrolni zdravi zubi su pozicionirani kao odraz ...u ogledalu. Rezultati: Dentalni karijes inicira neznatan porast OS u GCF. Primena različitih restorativnih materijala dovela je do sledećih efekata (efekti se smanjuju po navedenom redosledu): porast GSH u GCF: ZpoC>BF>GIC>Amg, porast aktivnosti tSOD: ZpoC>BF>Amg; i smanjenje MDA: ZpoC>ZPhC>Amg >TEC. ZpoC i ZPhC su pokazali najveći antioksidativni efekat, nasuprot GIC. Zaključak: Restauracije sa materijalima koji imaju antioksidativna svojstva mogu da redukuju bolesti desni inicirane karijesnom lezijom, što je od bitne kliničke važnosti u stomatologiji.

Abstract: Biocompatibility of dental materials (DMs) can be evaluated by gingival crevicular fluid (GCF) and oxidative stress (OS) status. The goal of the study was to ascertain influence of dental caries degree, teeth position and type and amount of applied DM on GCF OS profile. For this purpose we tested six DRMs that were used in one session: amalgam (Amg), composites: TetricEvoCeram (TEC) and Beautifil (BF), phosphate cement - zinc phosphate (ZPhC) and polycarboxylate cements - zinc polycarboxylate cements (ZpoC) and glass ionomer cement (GIC). Material and Methods: The study included 88 dental outpatients. Follow up was scheduled on the 7th and 30th day. Oxidative stress parameters [malondialdehyde (MDA) and glutathione (GSH) levels and total superoxide dismutase (tSOD]) activity were measured before (day zero) and after the treatment (7th and 30th day) in GCF. Healthy control teeth were positioned as reflection in the mirror. Results: Dental caries provokes insignific...ant rise of OS in GCF. The DMs accomplished following effects (listed in descending order): increase of GSH in GCF: ZPoC>BF>GIC>Amg; tSOD activity increase: ZPoC>BF>Amg; and MDA decrease: ZPoC>ZPhC>Amg>TEC. ZPoC and ZPhC showed the highest antioxidant effect, contrary to GIC. Conclusion: Restorations with antioxidant properties may reduce gum diseases initiated by caries lesion, which is of great clinical relevance in dentistry.

Faculty:
University of Kragujevac, Faculty of Medical Sciences
Date:
20-10-2021
Keywords:
karijes; parametri oksidativnog stresa; gingivalna sulkusna tečnost; dentalni ispun; glutation; lipidne peroksidacije; superoksid dismutaza / caries; oxidative stress parameters; oxidative stress; dental restorations; gingival crevicular fluid; glutathione; lipid peroxidation; superoxide dismutase
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_18994
URI
http://eteze.kg.ac.rs/application/showtheses?thesesId=8527
https://fedorakg.kg.ac.rs/fedora/get/o:1434/bdef:Content/download
https://nardus.mpn.gov.rs/handle/123456789/18994

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