Primena novih nanostrukturnih fotokatalizatora u razgradnji aktivnih supstanci odabranih farmaceutika u akvatičnom matriksu

Abstract

U okviru doktorske disertacije je ispitivana mogućnost implementacije novosintetisanih nanomaterijala (ZnO/SnO2, ZnO/In2O3, ZnO/TiO2) za fotokatalitičku dekompoziciju selektovanih nestereoidnih antiinflamatornih lekova. Sinteza novih nanomaterijala je sprovedena mehanohemijskom solid-state metodom. Niz laboratorijskih postupaka je sprovedeno sa ciljem utvrđivanja najoptimalnijih uslova fotokatalitičkog procesa pri kojim se postiže zadovoljavajuću procenat eliminacije ketoprofena, naproksena, diklofenaka i ibuprofena. Najintezivniji proces razgradnje je postignut u slučaju ketoprofena, dok je ibuprofen predstavljao najrezistentniji farmaceutik čija kompletna degradacija nije postignuta nakon jednočasovnog fotokatalitičkog tretmana. Dodatkom neorganskih konstituenata u akvatični rastvor farmaceutskih jedinjenja, promena degradacione konstante varira od porasta do pada u vrednosti. Inhibitorski uticaj na fotokatalitičku dekompoziciju farmaceutika su pokazali nitratni joni, dok poboljšanje procesa je postignuto dodatkom hloridnih jona. Kompetitivnim fotokatalitičkim reakcijama nesteroidnih antiinflamatornih lekova je pokazana zadovoljavajuća stabilnost i efikasnost nanostrukturnih materijala. Citotoksični testovi su sprovedeni sa ciljem utvrđivanja biokompatibilnost analiziranog naprednog oksidacionog procesa. Ekonomska analiza ukazuje da je primena novih nanomaterijala u fotokatalitičkom procesu isplatljiv proces sa mogućnošću primene u realnim industrijskim postrojenjima.

The possibility of implementation of newly synthesized nanomaterials (ZnO/SnO2, ZnO/In2O3, ZnO/TiO2) for photocatalytic decomposition of selected non - steroidal anti - inflammatory drugs was investigated within the doctoral dissertation. The synthesis of new nanomaterials was carried out by the mechanochemical solid-state method. A number of laboratory procedures were performed with the aim of determining the most optimal conditions of the photocatalytic process in which a satisfactory percentage of elimination of ketoprofen, naproxen, diclofenac and ibuprofen is achieved. The most intensive degradation process was achieved in the case of ketoprofen, while ibuprofen was the most resistant pharmaceutical whose complete degradation was not achieved after a one-hour photocatalytic treatment. By adding inorganic constituents to an aquatic solution of pharmaceutical compounds, the change in degradation constant varies from increase to decrease in value. Nitrate ions showed an inhibitory effect on the photocatalytic decomposition of pharmaceuticals, while the improvement of the process was achieved by the addition of chloride ions. Competitive photocatalytic reactions of nonsteroidal anti-inflammatory drugs have shown satisfactory stability and efficiency of nanostructured materials. Cytotoxicity tests were performed to determine the biocompatibility of the analyzed advanced oxidation process. Economic analysis indicates that the application of new nanomaterials in the photocatalytic process is a cost-effective process with the possibility of application in real industrial plants.