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Colorectal carcinoma: influence of systemic cytokine concentrations and pathohistological characteristics on anemia and thrombocytosis

dc.contributor.advisorJovanović, Marina
dc.contributor.otherJovanović, Milan
dc.contributor.otherZdravković, Nataša
dc.contributor.otherĐukić, Svetlana
dc.contributor.otherMirković, Darko
dc.creatorJocić, Miodrag
dc.date.accessioned2021-10-29T11:19:03Z
dc.date.available2021-10-29T11:19:03Z
dc.date.issued2021-04-22
dc.identifier.urihttp://eteze.kg.ac.rs/application/showtheses?thesesId=8146
dc.identifier.urihttps://fedorakg.kg.ac.rs/fedora/get/o:1377/bdef:Content/download
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/18704
dc.description.abstractU studiji su ispitivane sistemske koncentracije imunomodulacijskih proteina/interleukina i kliničko-patohistološke karakteristike bolesti i povezane su sa anemijom/trombocitozom kod obolelih od kolorektalnog karcinoma (CRC). Ispitanici sa CRC-om, su razvrstani u grupu sa anemijom, odnosno sa trombocitozom (eksperimentalne grupe) i grupu bez anemije, odnosno bez trombocitoze (kontrolne grupe). U ovako determinisanim skupovima ispitanika analizirane su kliničke (kompletna krvna slika sa brojem krvnih ćelija, vrednost hemoglobina, preocena aktivnosti bolesti, kompletan radiološki pregled, prisustvo komplikacija i pojava bolesti van gastrointestinalnog trakta) i patohistološke karakteristike bolesti (tip tumora, nuklearni i histološki gradus, TNM klasifikacija), kao i koncentracija citokina i imunomodulacijskih proteina (IL-1, IL-4, IL-10, IL-17, IL-33, galektina-1, galektina-3, TNF-α i INF-γ) i biohemijskih belega maligne bolesti (AFP,.CEA,.CA.19-9) u serumu bolesnika. Bolesnici sa CRCom i anemijom, odnosno trombocitozom imaju teži kliničko-patohistološki oblik bolesti (viši nuklearni i histološki gradus tumora, veći stepen invazije limfnih i krvnih sudova, viši TNM stadijum bolesti, više otkrivenih metastaza u plućima, jetri ili peritoneumu), u poređenju sa bolesnicima sa CRC-om bez anemije, odnosno bez trombocitoze. Takođe, utvrđena je pozitivna korelacija anemije, odnosno trombocitoze i sistemskih vrednosti interleukina, imunomodulacijskih proteina i biohemijskih belega maligne bolesti (AFP,.CEA,.CA.19-9) uhserumu bolesnika. Postoji pozitivna korelacija između sistemskih vrednosti imunomodulacijskih proteina i težeg kliničko-patohistološkog oblika bolesti, u odnosu na prisustvo anemije, odnosno trombocitoze kod bolesnika sa kolorektalnim karcinomom.sr
dc.description.abstractWe investigated systemic concentrations of immunomodulatory proteins/interleukins, as well as clinical and histopathological characteristics of the disease and correlated them with anemia/thrombocytosis in patients with colorectal cancer (CRC). The study included patients with colorectal cancer, divided into a group with anemia and a group with thrombocytosis (experimental groups) and a group without anemia, or without thrombocytosis (control groups). In such determined groups, clinical (complete blood count with blood cell count, hemoglobin value, disease activity, complete radiological examination, complications and occurrence of diseases outside the gastrointestinal tract) and pathohistological characteristics of the disease (tumor type, nuclear and histologic grade, TNM classification), as well as concentrations of cytokines and immunomodulatory proteins (IL-1, IL-4, IL-10, IL-17, IL-33, galectin-1, galectin-3, TNF-α and INF-γ) and biochemical indicators of malignant disease (AFP,.CEA,.CA.19-9) in the patients’ serum were analyzed. Patients with CRC and anemia/thrombocytosis, have a more severe clinical-pathohistological form of the disease (higher nuclear and histological grade of tumor, higher lymph and blood vessels invasion, higher TNM stage of the disease, more detectable lung, liver or peritoneum metastasis) compared to CRC patients without anemia or thrombocytosis. Moreover, a positive correlation between anemia/thrombocytosis, and cytokines, AFP,.CEA and.CA.19-9 values in the patients’ serum was determined. There is a positive correlation between the systemic values of immunomodulatory proteins and severe clinical-pathohistological form of the disease, based on the presence of anemia or thrombocytosis in CRC patients.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Крагујевцу, Факултет медицинских наукаsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Крагујевцуsr
dc.subjectkolorektalni karcinom, anemija, trobocitoza, citokini, IL-33, Gal-1sr
dc.subjectcolorectal carcinoma, anemia, thrombocytosis, cytokines, IL-33, Gal-1en
dc.titleKolorektalni karcinom: uticaj sistemskih koncentracija citokina i patohistoloških karakteristika na anemiju i trombocitozusr
dc.title.alternativeColorectal carcinoma: influence of systemic cytokine concentrations and pathohistological characteristics on anemia and thrombocytosisen
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/77381/Miodrag_Jocic_Medicinski.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/77380/Doctoral_thesis_11666.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_18704


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