Polimorfizmi gena lipidnog metabolizma kod pacijenata sa metaboličkim sindromom
Polymorphism of lipid metabolism genes in patients with metabolic syndrome
Committee membersStokić, Edita
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Metabolic syndrome is a complex polygene multifactor metabolic disorder. By knowing genetic predisposition, environment factors which are subject to change can be corrected, which allows the disorder to be postponed or prevented. Determining genetic background of metabolic syndrome is one of the necessary steps in preventing the disorder; it would save the cost of medical treatments as well as help in designing personalized therapy. Experiment goals are determining the connection between individual alleles of apoE and LRPI genes on one side and the appearance of metabolic syndrome on the other; the analysis of correlation between apoE and LRPI genes polymorphism and each individual anthropometric and biochemical parameter in both tested groups; as well as establishing the correlation of every composite genotype of apoE and LRPI genes with presence of metabolic syndrome, and the connection with each anthropometric and biochemical parameter in both tested groups. This paper has demonstra...ted the importance ofapoE gene and LRPI gene in the metabolism of lipids and in all other anthropometric and biochemical parameters tested and the impact of e4 allele form of apoE gene and T allele form of LRPI gene individually, as well as the impact of composite genotypes both of the above mentioned genes on the emergence and development of the metabolic syndrome. It has been determined that the most common allele form of apoE gene are e3, e4 and e2 subsequently, while the most common allele forms of LRP 1 gene is C in both test groups. It is concluded that in the experimental group more fi-equent is e4 allele of apoE gene and T allele ofLRPl gene, which confirms negative impact of stated alleles onto tested anthropometric and biochemical parameters. Acquired results show that presence ofe4 allele ofapoE gene increases the chance 11.5 times fur the metabolic syndrome compared to the carriers of e2 and e3 alleles, while T allele of LRPl gene increases the chance 4.76 times in comparison to C allele carriers.