Sinteza i antiproliferativna aktivnost novih D-homo i D-seko derivata androstana

Abstract

U prvom delu ove doktorske disertacije je izvršena sinteza novih derivata androstana sa D-laktonskom funkcijom ili D-seko derivata, sa modifikacijama u Ai/ ili B-prstenovima. U drugom delu je ispitana antiproliferativna aktivnost odabranih novosintetizovanih jedinjenja prema humanim tumorskim ćelijskim linijama (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29, K562) kao i prema zdravim ćelijama fetalnih fibroblasta pluća (MRC-5).

In first part of this work was achieved synthesis of some new androstane derivatives with D-lactone function and new D-seco derivatives with modification in A and/or B rings. In the second part the antiproliferative activity of selected newly synthesized compounds by human carcinoma cell lines (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29, K562) and the healthy cells of fetal lung fibroblasts (MRC-5 ) was examined.