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The influence of chronic pre-conditioning of phosphodiesterase 1 inhibitors alone and in combination with physical activity on functional recovery of an isolated heart of rats

dc.contributor.advisorFolić, Marko
dc.contributor.otherĐurić, Dušan
dc.contributor.otherJović, Slavoljub
dc.contributor.otherŽivković, Vladimir
dc.creatorRistić, Jelena S.
dc.date.accessioned2020-12-30T12:24:49Z
dc.date.available2020-12-30T12:24:49Z
dc.date.issued2020-10-29
dc.identifier.urihttp://eteze.kg.ac.rs/application/showtheses?thesesId=7830
dc.identifier.urihttps://fedorakg.kg.ac.rs/fedora/get/o:1304/bdef:Content/download
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/17759
dc.descriptionUvod: Redovna fizička aktivnost umerenog intenziteta se smatra neophodnom zdravstvenom merom kao osnovom nefarmakološke terapije kardiovaskularnih bolesti. Cilj ove studije je bio da proceni efekte PDEIs na kardiodinamske parametre i sistemski redoks status, nakon farmakološkog i fizičkog prekondicioniranja miokarda Materijal i metode: Studija je sprovedena na 96 mužjaka Wistar albino pacova, podeljenih u sledeće grupe sa i bez fizičkog treninga (12 po grupi): sedentarna kontrola, Nikardipin (6 mg/kg/dan), Vinpocetin (10 mg/kg/dan), Nimodipin (10 mg/kg/dan), trening umerenog intenziteta kontrolna grupa (MIT), Nikardipin (MIT + 6 mg/kg/dan leka), Vinpocetin (MIT + 10 mg/kg/dan leka), Nimodipin (MIT + 10 mg/kg/dan leka). Od kardidinamskih parametara praćeni su: dp/dt max, dp/dt min, SLVP, DLVP, frekvenca srca i koronarni protok. U koronarnom efluentu kao i u hemolizatu eritrocita životinja određivani su parametri oksidacionog stresa i antioksidacione zaštite: nitriti (NO2 – ), superoksidni anjonski radikal (O2), vodonik-peroksid (H2O2), indeks lipidne peroksidacije, superoksid dismutaza, katalaza i redukovani glutation. Rezultati: Prekondicioniranje PDE1 inhibitorima i treningom umerenog intenziteta povećavaju parametre kontraktilnosti srca, sa dominantnijim povećanjem dp/dt min i max kao i SPLK nakon primene vinpocetina i nimodipina i smanjuje oslobađanje pro-oksidanasa. Zaključak: Fizički trening umerenog inteziteta dovoljnog trajanja samostalno ili u kombinaciji sa PDE1 inhibitorima dovodi do razvijanja pozitivnih protektivnih adaptivnih mehanizama koji se manifestvuju smanjenjem oksidacionog stresa i poboljšanjem hemodinamskih parametara., a time i ukupne sposobnosti organizma.sr
dc.descriptionIntroduction: Regular physical activity of moderate intensity is considered a necessary health measure as a basis for non-pharmacological therapy of cardiovascular diseases. The aim of this study was to evaluate the effects of PDEIs on cardiodynamic parameters and systemic redox status, after pharmacological and physical myocardial preconditioning Material and methods: The study was performed on 96 male Wistar albino rats, divided into the following groups with and without physical training (12 per group): sedentary control, Nicardipine (6 mg/kg/day), Vinpocetine (10 mg/kg/day), Nimodipine (10 mg/kg/day), moderate intensity training control group (MIT), Nicardipine (MIT + 6 mg/kg/day), Vinpocetine (MIT + 10 mg/kg/day), Nimodipine (MIT) + 10 mg/kg/day). The following parameters were monitored: dp/dt max, dp/dt min, SLVP, DLVP, HR, CF and parameters of oxidative stress and antioxidant protection: nitrites (NO2 – ), superoxide anion radical (O2),hydrogen peroxide (H2O2), lipid peroxidation index (suzaroxide dismuta) , catalase (CAT) and reduced glutathione (GSH). Results: Preconditioning with PDE1 inhibitors and moderate-intensity training increase cardiac contractility parameters, with a more dominant increase in dp/dt min and max as well as SLVP after administration of vinpocetine and nimodipine, and decrease pro-oxidant release. Conclusion: Physical training of moderate intensity of sufficient duration alone or in combination with PDE1 inhibitors leads to the development of positive protective adaptive mechanisms which are manifested by reduction of oxidative stress and improvement of hemodynamic parameters, and thus the overall ability of the organism.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Крагујевцу, Факултет медицинских наукаsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceУниверзитет у Крагујевцуsr
dc.subjectinhibitori fosfodiesterazesr
dc.subjectphosphodiesterase inhibitorsen
dc.subjecttrening umerenog intenzitetasr
dc.subjectredoks statussr
dc.subjectkardiodinamski parametrisr
dc.subjectkoronarni protoksr
dc.subjectmoderate intensity trainingen
dc.subjectredox statusen
dc.subjectcardiodynamic parametersen
dc.subjectcoronary flowen
dc.titleUticaj hroničnog prekondicioniranja inhibitorima fosfodiesteraze 1 samostalno i u kombinaciji sa fizičkom aktivnošću na funkcionalni oporavak izolovanog srca pacovasr
dc.title.alternativeThe influence of chronic pre-conditioning of phosphodiesterase 1 inhibitors alone and in combination with physical activity on functional recovery of an isolated heart of ratsen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/67673/Disertacija.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/67674/Jelena_Ristic_Medicina.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_17759


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