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Hemijska, biohemijska i mikrobiološka karakterizacija Trifolium pratense L.

Chemical, biochemical and microbiological characterization of Trifolium pratense L.

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2014
Disertacija.pdf (6.042Mb)
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Author
Vlaisavljević, Sanja
Mentor
Kaurinović, Biljana
Committee members
Mimica-Dukić, Neda
Kaurinović, Biljana
Popović, Milan
Cvetković, Dragoljub
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Abstract
Hemijska karakterizacija ekstrakata  T. pratense L.  određena je LC-MS-MS, a etarskih ulja GC-MS analizom, pri čemu je  identifikovano više bioaktivnih jedinjenja.  Spektrofotometrijskim metodama ispitan je antioksidantni potencijal ekstrakata i etarskih ulja. Hepatoprotektivni efekat određen je  na  homogenatu i hemolizatu jetre laboratorijskih miševa.  Budući da  ova biljka ima visok sadržaj izoflavona, određena je  estrogena, antiestrogena aktivnost, kao i citotoksičnost ekstrakata. Antimikrobna  aktivnosta ekstrakata i etarskih ulja ispitana je na  šest bakterijskih sojeva.  Ekstrakti i etarska ulja su bili umereno aktivni u pogledu bioloških aktivnosti, osim u slučaju antimikrobne aktivnosti koju nije pokazao nijedan ispitivani uzorak.
The chemical characterization of  T.  pratense extracts was determined by LC-MS-MS, and the essential oils of the GC-MS analysis, wherein the  various  bioactive compounds were identified.  Antioxidant potential of extracts and essential oils was tested  by spectrophotometric methods.  Hepatoprotective  effect  was determined  in  haemolysate and liver homogenate of  laboratory  mice.  Estrogen, antiestrogen activity, as well  as the cytotoxicity of the extracts were  determined  due to the high content of isoflavones.  Antimicrobial activity of extracts and essential oils was  investigatied  on six bacterial strains. Essential oils and extracts were moderately active in terms of biological activity, except  in the case of   antimicrobial activity  where none of the extracts were active against tested bacterial strains.
Faculty:
University of Novi Sad, Faculty of Science
Date:
19-09-2014
Projects:
  • Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-172058)
Keywords:
Trifolium pratense L. / Trifolium pratense L. / slobodnoradikalske vrste / sekundarni metaboliti / antioksidantna aktivnost / hepatoprotektivni efekat / LC-MS-MS / GC-MS / estrogena aktivnost / antimikrobna aktivnost / free radical species / secondary metabolites / antioxidant activity / hepatoprotective effect / LC-MS-MS / GC-MS / estrogenic activity / antimicrobial activity
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http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija140360563076998.pdf?controlNumber=(BISIS)87893&fileName=140360563076998.pdf&id=2313&source=NaRDuS&language=sr
http://nardus.mpn.gov.rs/handle/123456789/1772
http://www.cris.uns.ac.rs/record.jsf?recordId=87893&source=NaRDuS&language=sr
http://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije14036056368993.pdf?controlNumber=(BISIS)87893&fileName=14036056368993.pdf&id=2314&source=NaRDuS&language=sr

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