Приказ основних података о дисертацији
Sinteza, karakterizacija i biološka aktivnost kompleksa Pd(II) sa etilendiaminskim i kumarinskim derivatima aminokiselina
Synthesis, characterization and biological activity of Pd(II) complexes with ethylendyamine and coumarine Amino acids derivatives
| dc.contributor.advisor | Jevtić, Verica | |
| dc.contributor.other | Trifunović, Srećko | |
| dc.contributor.other | Sabo, Tibor | |
| dc.contributor.other | Jelić, Ratomir | |
| dc.contributor.other | Radić, Gordana | |
| dc.creator | Stojković, Danijela | |
| dc.date.accessioned | 2020-10-24T12:30:56Z | |
| dc.date.available | 2020-10-24T12:30:56Z | |
| dc.date.issued | 2019-01-06 | |
| dc.identifier.uri | http://eteze.kg.ac.rs/application/showtheses?thesesId=7323 | |
| dc.identifier.uri | https://fedorabg.bg.ac.rs/fedora/get/o:1241/bdef:Content/download | |
| dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/17532 | |
| dc.description | U ovoj Doktorskoj disertaciji opisana je sinteza i karakterizacija nekoliko novih liganada, etilendiaminskih i kumarinskih derivata nekih aminokiselina i odgovarajućih paladijum(II)-kompleksa. Najpre je opisana sinteza i karakterizacija O,O'-dialkil estara (S,S)-etilen--diamin-N,N'-di-(2,2'-di-(4-hidroksi-benzil))sirćetne kiseline (H2-(S,S)-eddtyr). Ova jedinjenja su dobijena direktnom reakcijom između tetradentatnog liganda (S,S)-etilendiamin-N,N'-di-(2,2'-di-(4-hidroksi-benzil))sirćetne kiseline i odgovara- -jućeg apsolutnog alkohola (etanol, 1-propanol, 1-butanol i 1-pentanol) u molskom odnosu 1 : 2, uz uvođenje gasovitog hlorovodonika. Takođe, prikazana je i sinteza kumarinskih derivata nekih aminokiselina. Pomenuti ligandi dobijeni su refluktovanjem smeše 3-acetil-4-hidroksi kumarina, hidrohlorida metil estara aminokiselina S-valina, glicina, S-metionina ili S-triptofana i trimetilamina. Tok reakcije je praćen tankoslojnom hromatografijom (toluen : aceton = 8 : 2). Nakon završene reakcije, uparavanjem rastvarača do polovine svoje zapremine i dodavanjem 5 cm3 vode, dobijeni sukumarinski derivati sa pomenutim aminokiselinama. Strukture i sastav izolovanih liganada pretpostavljene su primenom elementalne mikroanalize, infracrvene, 1H i 13C NMR spektroskopije, a potvrđene na bazi rezultata rendgenske strukturne analize u slučaju metil 2-[(1-(2,4-dioksohroman-3-iliden)etilamino-3-metil)]butanoata. Dobijeni O,O'-dialkil estri (S,S)-etilendiamin-N,N'-di-(2,2'-di-(4-hidroksi--benzil))sirćetne kiseline su upotrebljeni za sintezu odgovarajućih paladijum(II)--kompleksa. Sastav dobijenih kvadratno-planarnih paladijuma(II)-kompleksa potvrđen je elementalnom analizom, dok je struktura izolovanih kompleksa pretpostavljena na osnovu infracrvene, 1H i 13C NMR spektroskopije. | sr |
| dc.description | The synthesis and characterization of several new ligands, ethylenediamine and coumarin derivatives of some amino acids and corresponding palladium(II)-complexes are described in this PhD thesis. Firstly, the synthesis and characterizations of O,O'-dialkyl esters of (S,S)-ethylenediamine- -N,N'-di-(2,2'-di-(4-hydroxy-benzyl)acetic acid, H2-(S,S)-eddtyr are described. These compounds were obtained by direct reaction between tetradentate ligand (S,S)-ethylenediamine-N,N'-di-(2,2'- -di-(4-hydroxy-benzyl)acetic acid and the corresponding absolute alcohol (ethanol, 1-propanol, 1-butanol, 1-pentanol) in a molar ratio 1:2 with the addition of gaseous hydrogen-chloride. Also, the synthesis of coumarin derivatives of some amino acids are also shown. Mentioned ligands were obtained refluxing a mixture of 3-acetyl-4-hydroxy coumarin, hydrochloride methyl esters of amino acids S-valine, glycine, S-methionine or S-tryptophan and trimethylamine. The progress of the reactions was monitored by TLC (toluene : acetone = 8 : 2). After the finishing of the reactions, the evaporation of solvent to the half of native volume and addition of 5 cm3 of water, the obtained coumarin derivatives with mentioned amino acids were obtained. The obtained O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-(2,2'-di-(4-hydroxy- -benzyl)acetic acids are used for synthesis of the corresponding palladium(II)-complexes. The composition of obtained square-planar palladium(II)-complexes was confirmed by elemental microanalysis, and the structure of isolated complexes is assumed on basis of infrared, 1H and 13C NMR spectroscopy. | en |
| dc.format | application/pdf | |
| dc.language | sr | |
| dc.publisher | Универзитет у Крагујевцу, Природно-математички факултет | sr |
| dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS// | |
| dc.rights | openAccess | en |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.source | Универзитет у Крагујевцу | sr |
| dc.subject | R2-(S | sr |
| dc.subject | S)-eddtyr ligandi | sr |
| dc.subject | kumarinski derivati aminokiselina Paladijum | sr |
| dc.subject | Kompleksna jedinjenja | sr |
| dc.title | Sinteza, karakterizacija i biološka aktivnost kompleksa Pd(II) sa etilendiaminskim i kumarinskim derivatima aminokiselina | sr |
| dc.title.alternative | Synthesis, characterization and biological activity of Pd(II) complexes with ethylendyamine and coumarine Amino acids derivatives | en |
| dc.type | doctoralThesis | en |
| dc.rights.license | BY-NC-SA | |
| dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/66134/Disertacija.pdf | |
| dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/66135/Izvestaj_Danijela_Stojkovic_PMF.pdf | |
| dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_17532 |
