Приказ основних података о дисертацији
Primena koncepta dizajna kvaliteta u razvoju lipofilnog krema sa biljnim ekstraktima i masnim uljima
| dc.contributor.advisor | Nešić, Ivana | |
| dc.contributor.other | Ibrić, Svetlana | |
| dc.contributor.other | Sunarić, Slavica | |
| dc.contributor.other | Živković, Jelena | |
| dc.contributor.other | Tadić, Vanja | |
| dc.creator | Stanković, Milica | |
| dc.date.accessioned | 2020-10-12T09:06:57Z | |
| dc.date.available | 2020-10-12T09:06:57Z | |
| dc.date.issued | 2020-06-08 | |
| dc.identifier.uri | http://eteze.ni.ac.rs/application/showtheses?thesesId=7546 | |
| dc.identifier.uri | https://fedorani.ni.ac.rs/fedora/get/o:1667/bdef:Content/download | |
| dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=17651721 | |
| dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/17491 | |
| dc.description | The aim of the PhD thesis was pharmaceutical development of lipophilic cream with active components of plant origin, which contains optimal combination of standardized fruit extract and fatty oil of blackthorn, dog rose, elderberry and rowanberry (Prunus spinosa L., Rosa canina L., Sambucus nigra L. and Sorbus aucuparia L., respectively), with satisfactory stability, safety, efficiency and applicative properties, using quality bу design concept. In vitro examination of ultrasonic fruit extracts with different solvents (methanol, 70% ethanol, 45% propylene glycol, purified water) included physico-chemical properties determination, polyphenolic compounds, organic acids and vitamins contents analyses, evaluation of antioxidant and anti-tyrosinase activity and influence on fibroblasts viability. As the richest source of bioactive compounds, with good antioxidative and anti-tyrosinase activity and positive influence on fibroblasts viability, an aqueous extract of rose hip at concentration of 3.5% was selected for incorporation into lipophilic cream. After the yields of fruit fatty oils obtained by Soxhlet and supercritical extraction were compared, a better efficiency of the supercritical extraction method for fatty oil isolation from seeds was found. Analysis of fatty acid content in the fruit and seed oils was carried out by gas chromatography. Blackthorn, rose hip and elderberry seed oils were selected for cream formulation at concentrations corresponding to the linoleic acid content of 0.815%. Organoleptic evaluation of lipophilic creams, physicochemical stability testing (pH value, electrical conductivity, centrifugation test) during the 12 months study, sensory characteristics analysis and in vivo estimation of irritation potential (as an aspect of skin application safety) and efficiency (effects on hydration, surface lipid content, skin pH, melanin index, as well as transepidermal water loss), showed that lipophilic cream with rose hip extract (35 mg/g) and blackthorn seed oil (22.4 mg/g) had optimal sensory characteristics, stability, favorable safety profile and the highest application efficiency, so it is suggested as potential pharmaceutical preparation for the treatment of dry skin, changes associated with atopic dermatitis (pruritis, xerosis, eczema), hyperpigmentations, UV radiation protection and oxidative stress, which lead to the loss of skin vitality and photoaging. | en |
| dc.format | application/pdf | |
| dc.language | sr | |
| dc.publisher | Универзитет у Нишу, Медицински факултет | sr |
| dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45017/RS// | |
| dc.rights | openAccess | en |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Универзитет у Нишу | sr |
| dc.subject | dizajn kvaliteta | sr |
| dc.subject | quality by design | en |
| dc.subject | lipofilni krem | sr |
| dc.subject | ekstrakti plodova trnjine | sr |
| dc.subject | masna ulja | sr |
| dc.subject | natkritična ekstrakcija | sr |
| dc.subject | linolna kiselina | sr |
| dc.subject | suva koža | sr |
| dc.subject | atopijski dermatitis | sr |
| dc.subject | oksidativni stres | sr |
| dc.subject | lipophilic cream | en |
| dc.subject | blackthorn | en |
| dc.subject | fatty oils | en |
| dc.subject | supercritical extraction | en |
| dc.subject | linoleic acid | en |
| dc.subject | dry skin | en |
| dc.subject | atopic dermatitis | en |
| dc.subject | oxidative stress | en |
| dc.subject | dog rose | en |
| dc.subject | elderberry and rowanberry fruit extracts | en |
| dc.subject | divlje ruže | sr |
| dc.subject | zove i jarebike | sr |
| dc.title | Primena koncepta dizajna kvaliteta u razvoju lipofilnog krema sa biljnim ekstraktima i masnim uljima | sr |
| dc.type | doctoralThesis | en |
| dc.rights.license | BY-NC-ND | |
| dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/65881/Disertacija.pdf | |
| dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/65882/Stankovic_Milica_I.pdf | |
| dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_17491 |
