Utvrđivanje povezanosti nivoa interleukina-6 i faktora transformacije rasta-beta sa kliničkim karakteristikama depresivnog poremećaja kod odraslih u odnosu na iskustvo zlostavljanja i/ili zanemarivanja u detinjstvu
Study of relationship between interleukin 6 and transforming growth factor - beta with clinical features of depressive disorder in adults versus experience of abuse and/or neglect in childhood
Author
Munjiza, AnaMentor
Lečić-Toševski, DušicaCommittee members
Marković, Ivanka
Isaković, Aleksandra

Vuković, Olivera
Mihajlović, Goran

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Show full item recordAbstract
Inflamatorna hipoteza u depresiji, postavljena pre dve decenije, ukazuje da kod
pacijenata sa depresivnim poremećajem dolazi do promene nivoa citokina u cirkulaciji, ali
dosadašnja istraţivanja nisu uspela da objasne razlike u nalazima koncentracija citokina u
razliĉitim studijama kao ni koje karakteristike depresije dovode do njihovih alteracija.
Novija saznanja ukazuju da su interleukin 6 (IL-6), kao predstavnik pro-inflamatornih
citokina, i faktor transformacije rasta beta (TGF-β), sa kljuĉnom ulogom u diferencijaciji T
regulatornih ćelija, ukljuĉeni u patofiziologiju pojave depresivnog poremećaja. Sa druge
strane poznato je da zlostavljanje i zanemarivanje u detinjstvu moţe biti prediktor razvoja
depresije kako kod dece tako i kod odraslih. Objedinjena analiza varijacija citokina kod
osoba koje boluju od depresije a koje u liĉnom iskustvu imaju zlostavljanje u detinjstvu, je
veoma redak podatak u dosadašnjim publikacijama.
Ciljevi: (1)Analizirati razlike u serumskoj koncentraciji I...L-6 i TGF-β kod pacijenata sa
depresivnim poremećajem i kod zdravih kontrola i ispitati razlike u koncentraciji IL-6 i
TGF-β izmeĊu razliĉitih kliniĉkih karakteristika kod osoba sa depresijom. (2) Ispitati
postojanje povezanosti nivoa IL-6 i TGF-β kod pacijenata sa depresivnim poremećajem u
odnosu na zlostavljanje i/ili zanemarivanje u deĉijem uzrastu.
Metod: Istraţivanje je koncipirano po tipu studije preseka i studije sluĉajeva i kontrola. U
studijsku grupu ukljuĉeno je 85 hospitalizovanih pacijenata Instituta za mentalno zdravlje
(Beograd), starosti od 18 do 65 godina, kojima je postavljena kliniĉka dijagoza prve
depresivne epizode ili rekurentnog depresivnog poremećaja. Kontrolna grupa je obuhvatila
71 zdravog dobrovoljca, koji su upareni po polu i godinama sa studijskom grupom. Od svih
pacijenata prikupljene su sociodemografske i kliniĉke karakteristike. Svi pacijenti su
ispitani Hamiltonovom skalom depresivnosti (HAMD), Hamiltonovom skalom
anksioznosti, Bekovim upitnikom depresivnosti (BDI) kao i Upitnikom o postojanju
zlostavljanja u detinjstvu (CTQ)...
Inflamatory hypothesis in depression, set two decades ago, is pointing that
in patients with major depressive disorder there is change in circulating levels of various
cytokines. Previous studies have not been able to explane differences in concentration of
cytokines as well as the characteristics of depression, which lead to alteration. Recent
findings indicate that interleukin 6 (IL-6), as representative of pro-inflammatory cytokines,
and transforming growth factor –beta (TGF-β), with a crucial role in differentiation of
regulatory T cells, are involved in pathogenesis of depressive disorder. On the other hand it
is well known that child abuse and neglect can be a predictor of depression in both
childhood and adolthood. Pooled analysis of variations of cytokine levels in patients with
depression and with previous history of abuse and/or neglect in childhood period – is a rare
finding in previous publications.
Aim: (1) To analyze differences between serum concentrations of IL-6 and TG...F-β in
patients with major depresive disorder vs. healthy controls, and to investigate possible
variationes of serum cytokine levels within difrent clinical features of depression. (2)
Investigate possible corelations of IL- 6 and TGF-β concentrations in patients with major
depresive disorder with relation to childhood abuse or/and neglect expiriences.
Method: The study was designed as a cross-sectional study and a study of cases and
controls. The study group included 85 patients hospitalized in Institute of Mental Health
(Belgrade), which are diagnosed with first or recurrent depressive episode, aged from 18 to
65 years. The control group included 71 healthy volunteers who were matched by gender
and age with the study group. Sociodemographic and clinical characteristics were gained
from all patients. All patients were evaluated by Hamilton Depression Rating Scale
(HAMD), Hamilton Anxiety Rating Scale, Beck Depression Inventory (BDI) and
Childhood Trauma Questionnaire (CTQ). The control group was taken socio-demographic
data, along with a completed BDI and CTQ. For determining levels of IL-6 and TGF-β in
serum were used commercial enzyme immunoassay tests (ELISA) (e-Biosciences)...