Приказ основних података о дисертацији
Uticaj galektina-3 na remodelovanje miokarda i rani klinički ishod kod pacijenata sa akutnim infarktom miokarda
| dc.contributor.advisor | Pavlović, Milan | |
| dc.contributor.other | Tomašević, Miloje | |
| dc.contributor.other | Nikolić, Valentina | |
| dc.creator | Andrejić, Olivera | |
| dc.date.accessioned | 2020-08-06T11:12:31Z | |
| dc.date.available | 2020-08-06T11:12:31Z | |
| dc.date.issued | 2020-02-06 | |
| dc.identifier.uri | http://eteze.ni.ac.rs/application/showtheses?thesesId=7453 | |
| dc.identifier.uri | https://fedorani.ni.ac.rs/fedora/get/o:1646/bdef:Content/download | |
| dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1026511853 | |
| dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/17306 | |
| dc.description | Our study investigated association between galectin-3 levels and adverse left ventricular remodelling at six months. Eighty-six patients following first AMI and stable angina (control group) were enrolled in this study and blood samples collected on day 1 from the femoral vein and artery, the right atrium near the coronary sinus and the aortic root; on day 5 from cubital vein and radial artery; on day 30 from the cubital vein. Patients with LVESV ≥ 20% at six months, were included in the LVR group. In patients with acute myocardial infarction, on day 1, Galectin-3 plasma levels in the femoral vein (10.34 ng/ml ± 3.81 vs 8.22 ng/ml ± 2.34, p=0.01), and coronary sinus (10.7 ng/ml ± 3.97 vs 8.41 ng/ml ± 2.56, p=0.007) were higher in the LVR group. Positive correlations between galectin-3 levels from aortic root and coronary sinus, aortic root and femoral vein, and coronary sinus and femoral vein were observed in both groups. On day 30, galectin-3 concentration in the cubital vein was an independent risk factor of LVR six months post-AMI, demonstrating 1.5-fold increased risk. Day-30 galectin-3 showed positive correlations with echocardiography parameters indicative of diastolic and systolic dysfunction. On day one galectin-3 levels in aortic root are significantly higher in patients with fatal outcome six months later. Determining galectin-3 plasma concentration on day 30 following AMI could have beneficial prognostic value in predicting LVR. | en |
| dc.format | application/pdf | |
| dc.language | sr | |
| dc.publisher | Универзитет у Нишу, Медицински факултет | sr |
| dc.rights | openAccess | en |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Универзитет у Нишу | sr |
| dc.subject | Galektin-3 | sr |
| dc.subject | Galectin-3 | en |
| dc.subject | myocardial infarction | en |
| dc.subject | remodelling | en |
| dc.subject | infarkt miokarda | sr |
| dc.subject | remodelovanje | sr |
| dc.title | Uticaj galektina-3 na remodelovanje miokarda i rani klinički ishod kod pacijenata sa akutnim infarktom miokarda | sr |
| dc.type | doctoralThesis | en |
| dc.rights.license | BY-NC-ND | |
| dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/64411/Disertacija.pdf | |
| dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/64412/Andrejic_Olivera.pdf | |
| dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_17306 |
