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Uticaj genskih polimorfizama enzima uključenih u metabolizam ksenobiotika na patogenezu i klinički tok hronične opstruktivne bolesti pluća

dc.contributor.advisorMilojković, Maja
dc.contributor.otherBojanić, Vladmila
dc.contributor.otherStanković, Ivana
dc.contributor.otherJevtović Stoimenov, Tatjana
dc.contributor.otherMihaljević, Olgica
dc.creatorMilačić, Nena N.
dc.date.accessioned2020-08-06T11:12:29Z
dc.date.available2020-08-06T11:12:29Z
dc.date.issued2019
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=7333
dc.identifier.urihttps://fedorani.ni.ac.rs/fedora/get/o:1638/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1026485741
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/17304
dc.descriptionThe results obtained show that the frequency of the heterozygous MDR1 C3435T is significantly higher in COPD patients in comparison to the control group (p <0.004). T allele MDR1 3435 was more common in smokers compared to non-smokers (p = 0.035). Within the clinical group, the number of leukocytes and sedimentation were in statistically significant correlation with the presence of altered T-allele of gene polymorphism MDR1 3435 (p = 0.012). The incidence of CYP3A5*1*3 (heterozygous form and homozygous form) was significantly higher in patients with COPD compared to those of the respondents (43.3% vs. 11.6%, p <0.001). The co-morbidity of COPD patients was statistically significantly more common in patients with non-functional CYP3A5 (p = 0.025). The pH values were statistically significantly higher in patients with functional form CYP3A5 (p = 0.046). The distribution of the genotype GG, GA and AA-308 TNF-α did not differ statistically in the group of patients with COPD compared to the control group of healthy subjects (p = 0.268). The number of neutrophils was statistically significantly higher in patients with COPD GG-308 TNF-α compared to A-allele carriers of this gene polymorphism (GA and AA-308 TNF-α) (p = 0.067). The pH value was significantly higher in patients with GG-308 TNF-α genotype carriers compared to carrier A-alleles of this gene polymorphism (GA and AA- 308 TNF-α) (p = 0.016). The GG-308 genotype TNF-α is the most common in COPD patients with BMI≤18.5 and in the BMI group of 18-24.9. Based on the obtained results, it can be concluded that the variant forms of genes encoding enzymes involved in the xenobiotic metabolism - MDR1 C3435T and CYP3A5*3 are significantly more frequently present in patients with COPD compared to the control group of healthy subjects. In addition, the number of leukocytes and sedimentation are in correlation with the changed genetic status of MDR1 C3435T, and comorbidities are significantly more common in patients with non-functional CYP3A5*3. Genetic status of GA-308 TNF-α was statistically significantly related to the number of neutrophils, whereas the presence of T-allele-308 TNF-α was not more common in patients with COPD compared to healthy subjects.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Медицински факултетsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Нишуsr
dc.subjectHOBPsr
dc.subjectCOPDen
dc.subjectpolimorfizmi jednog nukleotidasr
dc.subjectMDR1sr
dc.subjectTNF-αsr
dc.subjectCYP3A5sr
dc.subjectsingle nucleotide polymorphismsen
dc.subjectMDR1en
dc.subjectTNF-αen
dc.subjectCYP3A5en
dc.titleUticaj genskih polimorfizama enzima uključenih u metabolizam ksenobiotika na patogenezu i klinički tok hronične opstruktivne bolesti plućasr
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/64406/Disertacija.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_17304


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