Biološka aktivnost novosintetisanih D-seko i D-homo-estratrienskih derivata u in vivo i in vitro uslovima
Biological activity of the newly synthesized D-secoand D-homoestratriene derivatives in in vivo and in vitro experiments
Author
Jovanović-Šanta, SuzanaMentor
Mimica-Dukić, Neda
Committee members
Sakač, MarijaMimica-Dukić, Neda
Kovačević, Radmila
Popović, Milan
Metadata
Show full item recordAbstract
Sintetisana su nova jedinjenja, 16- i 17-supstituisani 16,17-sekoestratrienski derivati i D-homoestranski derivati, polazeći od 3-benziloksi-17-hidroksi-16,17-sekoestra-1,3,5(10)-trien-16-nitrila. Ispitana je estrogena i antiestrogena aktivnost u eksperimentima in vivo, antiaromatazna aktivnost in vitro, antioksidantna aktivnost DPPH i TBA testom, kao i antiproliferativna aktivnost prema ćelijskim linijama MCF-7 ATCC, MDA-MB-231, HT-29 i MRC-5 novosintetisanih jedinjenja.
Some new compounds, 16- and 17-substituted 16,17-secoestratriene derivatives, as well as D-homoestratriene derivatives, were synthesized, starting from 3-benzyloxy-17-hydroxy-16,17-secoestra-1,3,5 (10)-triene-16-nitrile. The newly synthesized compounds were tested for their in vivo estrogenic and antiestrogenic activity, in vitro antiaromatase activity, antioxidative activity by DPPH and TBA tests, as well as antiproliferative activity against MCF-7 ATCC, MDA-MB-231, HT-29 i MRC-5 cell lines.