Ispitivanje korelacije između hemijske strukture, fizičko-hemijskih i retencionih parametara u hromatografiji na obrnutim fazama novosintetisanih derivata s-triazina
Study of the correlation between chemical structure, physicochemical and retention parameters of newly synthesized s-triazine derivatives by reversed-phase chromatography
Abstract
Primenom tečne hromatografije na obrnutim fazama ispitano je retenciono ponašanje 14 novosintetisanih derivata s-triazina na tankom sloju RP C-18 i silika gelu impregniranim parafinskim uljem. Kao pokretne faze korišćene su dvokomponentne smeše vode i organskih rastvarača. Izračunate su RM0 vrednosti i ispitana je korelacija sa različitim deskriptorima i prediktorima biološke aktivnosti.
Retentional behaviour of 14newly syntetised derivates of s-triazine on RP C-18 and paraffin oil-impregnated silica gel suport had been investigated using thin-layer chromatography. As a mobilephases were used two-component water based mobile phases. Calculated RM0 values were corelated to various molecular descriptors as well as biological activity indicators.