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Sinteza i biološka aktivnost novih steroidnih heterocikličnih jedinjenja

Synthesis and biological activity of new steroidal heterocyclic compounds

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2015
Disertacija.pdf (10.91Mb)
IzvestajKomisije.pdf (256.6Kb)
Author
Oklješa, Aleksandar
Mentor
Penov-Gaši, Katarina
Committee members
Čanadi, Janoš
Penov-Gaši, Katarina
Đurendić, Evgenija
Sakač, Marija
Đilas, Sonja
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Abstract
U ovoj doktorskoj disertaciji ispitane su 1,3-dipolarne cikloadicione reakcije steroidnih azido-nitrila, nitrona i nitril-oksida, pri čemu su sintetizovana različita heterociklična steroidna jedinjenja androstanske i estranske serije. Utvrdjene su strukture novosintetizovanih jedinjenja. Ispitana je biološka aktivnost odabranih jedinjenja.
In this PhD thesis 1,3-dipolar cycloadditions of steroidal azido-nitriles, nitrones and nitrile-oxide were examined. Various steroidal heterocyclic compounds in the androstane and estrane series were synthesised. The structural characterisation of newly synthesised compounds was done. Biological activity of selected compounds was examined.
Faculty:
University of Novi Sad, Faculty of Science
Date:
24-07-2015
Projects:
  • Synthesis, characterization and biological investigation of steroid derivatives and their molecular aggregates (RS-172021)
Keywords:
Sinteza / Synthesis / steroidi / androgeni / estrogeni / D-seko derivati / D-homo derivati / tetrazoli / oksimi / nitril-oksid / izoksazol nitroni / izoksazolini / citotoksičnost / 1 / 3-dipolarna cikloadicija / „click" hemija / mikrotalasna potpomognuta sinteza / steroids / androgen / estrogen / D-seco derivatives / D-homo derivatives / tetrazoles / oximes / nitrile oxide / isoxazole / nitrones / isoxazolines / cytotoxicity / 1 / 3-dipolar cycloaddition / "click" chemistry / microwave assisted synthesis
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http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija144257331444161.pdf?controlNumber=(BISIS)94966&fileName=144257331444161.pdf&id=4332&source=NaRDuS&language=sr
http://nardus.mpn.gov.rs/handle/123456789/1687
http://www.cris.uns.ac.rs/record.jsf?recordId=94966&source=NaRDuS&language=sr
http://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije143281643749918.pdf?controlNumber=(BISIS)94966&fileName=143281643749918.pdf&id=3768&source=NaRDuS&language=sr

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