Prikaz osnovnih podataka o disertaciji
Nove izostere i bioizostere prirodnih stiril-laktona: dizajn, sinteza i antiproliferativna aktivnost
Novel isosteres and bioisosteres of natural styryl lactones: design,synthesis and antiproliferative activity
dc.contributor.advisor | Popsavin, Velimir | |
dc.contributor.other | Popsavin, Mirjana | |
dc.contributor.other | Popsavin, Velimir | |
dc.contributor.other | Đurendić, Evgenija | |
dc.contributor.other | Sakač, Marija | |
dc.contributor.other | Šolaja, Bogdan | |
dc.creator | Francuz, Jovana | |
dc.date.accessioned | 2015-12-29T11:16:28Z | |
dc.date.available | 2015-12-29T11:16:28Z | |
dc.date.available | 2020-07-03T13:42:29Z | |
dc.date.issued | 2015-04-14 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/1675 | |
dc.identifier.uri | http://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija143039209607936.pdf?controlNumber=(BISIS)93661&fileName=143039209607936.pdf&id=3638&source=NaRDuS&language=sr | sr |
dc.identifier.uri | http://www.cris.uns.ac.rs/record.jsf?recordId=93661&source=NaRDuS&language=sr | sr |
dc.identifier.uri | http://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije142256624654576.pdf?controlNumber=(BISIS)93661&fileName=142256624654576.pdf&id=3244&source=NaRDuS&language=sr | sr |
dc.description.abstract | U radu su ostvarene višefazne sinteze većeg broja analoga prirodnih stiril-laktona (+)-goniofufurona i 7-epi-(+)-goniofufurona polazeći iz D-glukoze. Ispitana je in vitro citotoksičnost sintetizovanih analoga prema devet malignih i jednoj zdravoj ćelijskoj liniji. Uspostavljeni su korelacioni odnosi izmedju strukture i antiproliferati vne aktivnosti sintetizovanih proizvoda, pored toga uradjeni su i dodatni biološki testovi koji se odnose na dokazivanje mehanizma citotoksičnog dejstva pomenutih stiril-laktona i analoga. | sr |
dc.description.abstract | Multistep synthesis of a number of natural styryl lactones goniofufurone and 7-epi-goniofufurone analogues was achieved starting f rom D-glucose. In vitro cytotoxicity of newly synthetized analogues against nine human tumour cell lines and against a single normal cell line was evaluated. Structure-activity relationships were established for both natural products and analogues. Some additional biological tests related to the cell mechanisms underlying the cytotoxicity of the mentioned styryl lactones and analogues, were also carried out. | en |
dc.language | sr (latin script) | |
dc.publisher | Универзитет у Новом Саду, Природно-математички факултет | sr |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Универзитет у Новом Саду | sr |
dc.subject | Citotoksični stiril-laktoni | sr |
dc.subject | Cytotoxic styryl lactones | en |
dc.subject | goniofufuron | sr |
dc.subject | 7-epi-goniofufuron | sr |
dc.subject | D-glukoza | sr |
dc.subject | sintezaanaloga | sr |
dc.subject | izostere | sr |
dc.subject | bioizostere | sr |
dc.subject | antiproliferati vna aktivnost | sr |
dc.subject | SAR | sr |
dc.subject | goniofufurone | en |
dc.subject | 7-epi-goniofufurone | en |
dc.subject | D-glucose | en |
dc.subject | synthesis of analogues | en |
dc.subject | isosteres | en |
dc.subject | bioisosteres | en |
dc.subject | antiproliferati ve activity | en |
dc.subject | SAR | en |
dc.title | Nove izostere i bioizostere prirodnih stiril-laktona: dizajn, sinteza i antiproliferativna aktivnost | sr |
dc.title | Novel isosteres and bioisosteres of natural styryl lactones: design,synthesis and antiproliferative activity | en |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Попсавин Велимир; Ђурендић Евгенија; Сакач Марија; Попсавин Мирјана; Попсавин Велимир; Шолаја Богдан; Француз Јована; Нове изостере и биоизостере природних стирил-лактона: дизајн, синтеза и антипролиферативна активност; Нове изостере и биоизостере природних стирил-лактона: дизајн, синтеза и антипролиферативна активност; | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/37955/Disertacija.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/37956/IzvestajKomisije.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/37956/IzvestajKomisije.pdf | |
dc.identifier.fulltext | https://nardus.mpn.gov.rs/bitstream/id/37955/Disertacija.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_1675 |