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Cognitive dysfunctions and metabolic syndrome in disease of the small blood vessels of the brain

dc.contributor.advisorTončev, Gordana
dc.contributor.otherĐukić, Aleksandar
dc.contributor.otherJanjić, Vladimir
dc.contributor.otherDinčić, Evica
dc.creatorBošković-Matić, Tatjana
dc.date.accessioned2020-02-26T15:44:55Z
dc.date.available2020-02-26T15:44:55Z
dc.date.available2020-07-03T15:20:25Z
dc.date.issued2019-12-23
dc.identifier.urihttp://eteze.kg.ac.rs/application/showtheses?thesesId=7244
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/12016
dc.identifier.urihttps://fedorakg.kg.ac.rs/fedora/get/o:1229/bdef:Content/download
dc.description.abstractBolest malih krvnih sudova mozga podrazumeva nekoliko kliničkih sindroma koji proističu iz oštećenja zida ili začepljenja malih krvnih sudova unutar moždanog tkiva. Udružena je sa faktorima rizika kao što su hipertenzija, dislipidemija, dijabetes, gojaznost, ishemijska bolest srca, pušenje i zloupotreba alkohola. Jedan od potencijalnih faktora rizika za nastanak bolesti malih krvnih sudova mozga je metabolički sindrom. Bolest se klinički manifestuje neuroškim simptomima, kognitivnim disfunkcijama i depresijom. Istraživanje je sprovedeno kod pacijenata koji su hospitalizovani na Klinici za neurologiju KC Kragujevcu u periodu od 01.02.2017. do 31.12.2017. godine, kod kojih je neuroradiološki potvrđena bolest malih krvnih sudova (magnetnom rezonancom endokranijuma). Bilo je uključeno 49 odraslih bolesnika sa bolešću malih krvnih sudova mozga (24 sa lakunarnim infarktima i 25 sa ishemijskim, hiperintenzivnim lezijama bele mase). Kontrolnu grupu činilo je 25 neuroloških pacijenata sa urednim nalazom na magnetnoj rezonanci endokranijuma, sličnog pola i starosti. Sa pacijentima je postupano prema lokalnim smernicama i kliničkim putevima koji nisu povezani sa ovom studijom, već predstavljaju deo rutinske nege neuroloških bolesnika u Kliničkom centru Kragujevac. Rezultati prikazani u ovom radu ukazuju da je bolest malih krvnih sudova mozga praćena slabljenjem kognitivne sposobnosti i depresivnim simptomima, pri čemu pacijenti sa lakunarnim infarktima imaju slabiju kogniciju i izraženije depresivne simptome od pacijenata sa hiperintenzivnim lezijama bele moždane mase. Takođe, pacijenti sa bolešću malih krvnih sudova mozga koji imaju i metabolički sindrom su više depresivni i manje kognitivno sposobni od pacijenata sa bolešću malih krvnih sudova mozga, ali bez metaboličkog sindroma.sr
dc.description.abstractDisease of the small blood vessels of the brain involves several clinical syndromes arising from damage to the wall or obstruction of the small blood vessels inside the brain tissue. It is associated with risk factors such as hypertension, dyslipidemia, diabetes, obesity, ischemic heart disease, smoking and alcohol abuse .One of the potential risk factors for developing cerebral small vessels disease is the metabolic syndrome. The disease is clinically manifested by neurological symptoms, cognitive dysfunctions and depression. The study was conducted in patients hospitalized at the Kragujevac Clinic for Neurology in the period from 01.02.2017. to 31.12.2017, in which neuroradiologically confirmed disease of the small blood vessels (magnetic resonance imaging of the endocranium). There were 49 adult patients with small cerebral blood vessels disease (24 with lacunar infarctions and 25 with ischemic, hyper intense white mass lesions). The control group consisted of 25 neurological patients with neat endocranial magnetic resonance imaging, of similar sex and age. Patients were treated according to local guidelines and clinical pathways not associated with this study, but are part of the routine care of neurological patients at the Clinical Center Kragujevac. The results presented in this paper indicate that cerebral small vessels disease is accompanied by impaired cognitive ability and depressive symptoms, whereby patients with lacunar infarctions have poorer cognition and more severe depressive symptoms than patients with hyper intensive white brain lesions. Also, patients with cerebral small vessels disease who also have metabolic syndrome are more depressed and less cognitively able than patients with cerebrovascular disease but no metabolic syndrome.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Крагујевцу, Факултет медицинских наукаsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceУниверзитет у Крагујевцуsr
dc.subjectbolest malih krvnih sudovasr
dc.subjectCerebral small vessels diseaseen
dc.subjectmetabolički sindromsr
dc.subjectkognitivni poremećajisr
dc.subjectdepresivnostsr
dc.subjectmetabolic syndromeen
dc.subjectcognitive dysfunctions and depressionen
dc.titleKognitivni poremećaji i metabolički sindrom kod bolesti malih krvnih sudova mozgasr
dc.title.alternativeCognitive dysfunctions and metabolic syndrome in disease of the small blood vessels of the brainen
dc.typedoctoralThesisen
dc.rights.licenseBY
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/50212/Tatjana_BoskovicMatic_Medicinski.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/50211/Disertacija.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_12016


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