Analiza savetovanja trudnica o upotrebi antiinfektivnih i antiinflamatornih lekova tokom trudnoće
Analysis of pregnant women advising about the use of anti-infective and anti-inflammatory drugs during pregnancy
Метаподаци
Приказ свих података о дисертацијиСажетак
Lekovi mogu delovati štetno u bilo kom razdoblju trudnoće, te se samo mali
broj njih smatra potpuno bezbednim za upotrebu u toku trudnoće. Procena rizika i primena odgovarajuće terapije je vrlo važna. Cilj ovog rada je da ispita sve faktore povezane sa procenom visokog rizika od strane kliničkih farmakologa u trudnica kojima su propisani anti-infektivni lekovi i blagi analgetici.
Sprovedena je studija-preseka u koju je uključeno 284 trudnica koje su dolazile po savet u Službu za kliničku farmakologiju Kliničkog centra Kragujevac , u periodu od 1997. do
2012. godine. Sve trudnice su koristile neke od anti-infektivnih lekova i blagih
analgetika tokom prva tri meseca trudnoće. Podaci su prikupljeni iz medicinskih
kartona pacijentkinja i putem telefonskih intervjua..
Klinički farmakolozi su procenili rizik od pojave kongenitalnih anomalija kao
„visok“ kod trudnica koje su bile na terapiji tetraciklinima i derivatima propionske
kiseline tokom perioda trudnoće. Poremećaji u razvoju p...rema podacima datim od majki,
su bili povezani sa primenom cefalosporina u toku prva tri meseca trudnoće. Spontani
i namerni pobačaji su bili češći kod trudnica koje su bile na terapiji tetraciklinima
tokom trudnoće.
Procena rizika od kongenitalnih anomalija data od strane klinički farmakologa je deo
rutinske prakse i u najvećoj meri zavisi od dostupne, publikovane literature i znanja o
beznednosti datog leka tokom trudnoće, naročito u prva tri meseca.
Considering that small number of drugs are completely safe for use during pregnancy, right choice and adequate risk assessment is extremely important. The aim of this study was to analyze factors associated with estimate of high teratogenic risk (as judged by clinical pharmacologist) in pregnant females who were prescribed anti-infective drugs or mild analgesics.
A cross-sectional study included 284 pregnant women who came for an advice about teratogenic risk to clinical pharmacologist in Clinical Centre Kragujevac, Serbia during the period from 1997
to 2012. All of included pregnant women were prescribed mild analgesics and/or anti-infective
drugs during the first 3 months of pregnancy. The data were collected from patient files and by
phone interviews.
Clinical pharmacologists estimated the risk of teratogenicity as “high” in pregnant females who
were using tetracyclines or propionic acid derivatives. Disorders of development reported by
mothers during phone interviews were as...sociated with cephalosporin use during first 3 months of
pregnancy, while miscarriages or abortions happened more often in women who used a
tetracycline.
Estimate of risk from congenital anomalies after use of drugs during pregnancy, which make
clinical pharmacologists as part of their routine healthcare services, depends on amount of
published data about previous experiences with specific drugs during the first 3 months of
pregnancy.