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Oxidative stress and trace elements balance in patients during in vitro fertilization cycles

dc.contributor.advisorVidaković, Snežana
dc.contributor.otherPlamenac Bulat, Zorica
dc.contributor.otherVasiljević, Mladenko
dc.contributor.otherSpremović-Rađenović, Svetlana
dc.contributor.otherPopović, Jasmina
dc.creatorTulić, Lidija
dc.date.accessioned2020-01-27T12:21:37Z
dc.date.available2020-01-27T12:21:37Z
dc.date.available2020-07-03T08:46:20Z
dc.date.issued2019-09-20
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=7132
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/11777
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:20805/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=51733007
dc.description.abstractUvod: Oksidativni stres dešava se usled neuravnoteženog odnosa pro-oksidanata i antioksidanata u prilog poslednjih. Odnos može biti poremećen zbog povećane koncentracije reaktivnih kiseoničnih vrsta (ROS) i/ili umanjene antioksidativne odbrane. Normalne fiziološke funkcije, uključujući proces signalizacije ćelija, proliferacije i diferencijacije, zavise od prisustva određenih koncentracija ROS. U reproduktivnom traktu, fiziološki nivoi ROS neophodni su ne samo za ovulaciju, već i za interakciju oocita-spermatozoid, fertilizaciju, implantaciju i rani razvoj embriona. Ipak, povećana produkcija ROS može da ošteti prirodnu antioksidativnu odbranu organizma, remeteći mikrosredinu u reproduktivnom traktu i normalne fiziološke reakcije. Razumevanje uloge ROS u ženskom infertilitetu i dalje je nepotpuno. Činjenica da su oksidativni i antioksidativni sistem prisutni u različitim ženskim reproduktivnim tkivima sugeriše da infertilitet i određenja reproduktivna oboljenja mogu biti uzrokovana, makar delimično, oksidativnim stresom. Već godinama se sve više smatra da oksidativni stres (OS) ima negativan uticaj na reproduktivne sposbnosti i muškaraca i žena. Doprinos OS patogenezi infertiliteta sve se obimnije ispituje u oblasti muškog infertiliteta, posebno u pogledu uticaja na različite aspekte kvaliteta spermatozoida. Cilj: Ciljevi ove studije bili su da se kod pacijenata uključenih u postupak VTO ispita uticaj različitih protokola kontrolisane ovarijalne stimulacije (KOS), doze gonadotropina, promene koncetracija parametara OS pre stimulacije i posle stimulacije na ishod IVF postupka. Takođe smo ispitivali povezanost promene koncentracije parametara oksidativnog stresa, poremećaja ravnoteže bioelemenata i uticaj toksičnih metala kod žena na ishod IVF postupka kod žena, dok smo kod muških partnera ispitivali povezanosti promene koncentracija parametara oksidativnog stresa, poremećaja ravnoteže bioelemenata i uticaj toksičnih metala sa parametrima spermograma i ispitivali uticaj parametara spermograma na ishod postupka...sr
dc.description.abstractBackground: Oxidative stress occurs due to the unbalanced relationship pro-oxidants and antioxidants in favor of the latter. The relationship can be disrupted due to the increased concentration of reactive oxygen species (ROS) and / or reduced antioxidant defense. Normal physiological functions, including the process of cell signaling, proliferation and differentiation, depend on the presence of certain concentrations of ROS. In the reproductive tract, physiological levels of ROS are essential not only for ovulation, but also for oocyte-sperm interaction, fertilization, implantation and early embryo development. However, the increased production of ROS can damage the body's natural antioxidant defenses, disrupting microenvironment in the reproductive tract and normal physiological reactions. Understanding the role of ROS in the female and male infertility is still incomplete. The fact that the oxidative stress and antioxidant system are present in a different female reproductive tissues suggests that infertility and other reproductive disorders can be caused, at least in part, by oxidative stress. It is considered that oxidative stress (OS) has a negative impact on the reproductive abilities of both men and women. Contribution of OS in pathogenesis of infertility is extensively investigated in the field of male infertility, particularly in terms of impact on different aspects of sperm quality. Objective: The aims of this study were to investigate the effect of different protocols of controlled ovarian stimulation (COS), doses of gonadotropins, changes in OS parameters OS prior to stimulation and after stimulation on IVF outcome. We also examined the association between the changes of OS parameters and trace elements in women on IVF outcome in women, while on male partners we examined the association between oxidative stress parameters and trace elements and semen parameters as well as the influence of semen parameters on IVF outcome. Design and Methods: The study included 107 consecutive women and 52 men involved in the process of in vitro fertilization (IVF) at the Department of Obstetrics and Gynecology, Clinical Center of Serbia. Women were divided into three groups...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectoksidativni stressr
dc.subjectoxidative stressen
dc.subjecttrace elementsen
dc.subjecttoxic metalsen
dc.subjectIVFen
dc.subjectbioelementisr
dc.subjectteški metalisr
dc.subjectIVFsr
dc.titleOksidativni stres i ravnoteža bioelemenata kod pacijentkinja u postupku vantelesnog oplođenjasr
dc.title.alternativeOxidative stress and trace elements balance in patients during in vitro fertilization cyclesen
dc.typedoctoralThesis
dc.rights.licenseBY
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/8323/IzvestajKomisije21631.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/8322/Disertacija.pdf


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