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The effect of long-term dietary restriction on insulin signaling pathway in rat brain during aging

dc.contributor.advisorKanazir, Selma
dc.contributor.otherMladenović-Đorđević, Aleksandra
dc.contributor.otherSmiljanić, Kosara
dc.creatorTodorović, Smilja
dc.date.accessioned2019-11-15T10:03:56Z
dc.date.available2019-11-15T10:03:56Z
dc.date.available2020-07-03T08:07:48Z
dc.date.issued2019-07-01
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=6913
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/11506
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:20262/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1025218994
dc.description.abstractStarenje je normalan, fiziološki proces koji obuhvata sve organe i organske sisteme i tokom koga se organizam suočava sa nizom strukturnih i funkcionalnih promena. Starenje mozga je izrazito kompleksan proces, predstavljen nizom sukcesivnih događaja koji postepeno rezultiraju gubitkom kognitivnih i motornih funkcija. Postoji niz farmakoloških i sredinskih faktora koji su u stanju da odlože i/ili uspore mnoge od starosno-zavisnih procesa, a dijetalna restrikcija (DR) je jedna od najviše i najduže istraživanih. Mnogobrojni su eksperimentalni i epidemiološki podaci koji govore u prilog korisnih efekata restriktivnog režima ishrane, bez obzira da li se radi o svakodnevnoj, ili intermitentnoj dijeti, smanjenju količine hrane ili kalorija. Međutim, u poslednje vreme se sve više pojavljuju podaci koji dovode u pitanje univerzalnost korisnog dejstva dijete. Da bi ovakva intervencija postigla svoj optimalni efekat, neophodno je povesti računa o određenim specifičnostima prilikom uspostavljanja restriktivnog režima ishrane. Pre svega, pokazano je da stepen restrikcije igra bitnu ulogu u efektima koje ona proizvodi i da previše restriktivan režim ishrane može imati negativne posledice po organizam. Takođe, postoje indicije da nisu svi organski sistemi podjednako podložni procesima starenja, kao ni dejstvu dijete. Efekat dijete se može veoma razlikovati u zavisnosti od stepena i tipa restrikcije, pola i organa gde se efekat očekuje, kao i od starosti jedinke na koju se restriktivni režim primenjuje. Prvi korak u istraživanju korisnih efekata restrikcije hrane koja je iznosila 60% prosečnog dnevnog unosa hrane, bio je ispitati efekat različitih dijetalnih režima, odnosno efekte DR koja je različito trajala i koja je započeta u različitim životnim dobima kod mužjaka Wistar soja pacova. Praćen je čitav niz parametara u aktivnosti životinja i detektovane su značajne razlike u njihovim fizičkim i kognitivnim preformansama, kako tokom starenja, tako i pod uticajem različitih režima ishrane. Dugotrajna dijetalna restrikcija otpočeta u adultnom dobu je dovela do poboljšanja u izvođenju motoričkih i kognitivnih testova i do sveukupnog poboljšanog stanja organizma, što se ogledalo u smanjenoj krhkosti ovih životinja...sr
dc.description.abstractAging is a normal, physiological process that involves all organs and organic systems, and during which the organism faces a number of structural and functional changes. Brain aging is an extremely complex process, represented by a series of successive events that gradually result in loss of cognitive and motor functions. There are a number of pharmacological and environmental factors that are able to postpone and / or slow down many of the age-dependent processes, and dietary restriction (DR) is one of the most investigated and most widely used experimental intervention in aging research. There are numerous experimental and epidemiological data that support the beneficial effects of a restrictive diet, regardless of the type: a daily reduction or intermittent diet, reduction in food or in calories, all of those approaches seem beneficial. Nevertheless, there is a body of data that challenges current premise about comprehensive DR usefulness. In order for DR to achieve its optimal effect, it is necessary to take certain specificities into account while establishing a restrictive dietary regime. First of all, it has been shown that the percentage of restriction plays an important role in the effects it induces, and that a very restrictive diet may have negative consequences for the organism. In addition, not all the body systems are equally susceptible to aging processes, nor to the beneficial effects of DR. The effect of the restrictive diet can vary greatly, depending on the degree and type of restriction, gender and organs examined, as well as the age of the individual to which the restrictive regimen is applied. In order to investigate the effect of 60% DR on the energy homeostasis and insulin signaling in the brain, we first examined the effects of three different types of dietary restriction that varied in length and onset, on rat behavior during aging. The experiments were performed on 12-, 18- and 24-month-old male Wistar rats exposed to AL or DR type of feeding (60% of AL daily intake). A variety of parameters were monitored in the activities of animals and significant differences in their physical and cognitive performance were detected, both during aging and under the influence of different dietary regimes...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Биолошки факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173056/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143004/RS//
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectmozaksr
dc.subjectdietary restrictionen
dc.subjectdijetalna restrikcijasr
dc.subjectstarenjesr
dc.subjectkrhkostsr
dc.subjectmotorička aktivnostsr
dc.subjecthabituacijasr
dc.subjectprostorna memorijasr
dc.subjectenergetska homeostazasr
dc.subjectmetabolizam glukozesr
dc.subjectinsulinsr
dc.subjectagingen
dc.subjectfrailtyen
dc.subjectmotor activityen
dc.subjecthabituationen
dc.subjectspatial memoryen
dc.subjectglucose metabolismen
dc.subjectenergy homeostasisen
dc.subjectinsulinen
dc.subjectbrainen
dc.titleUticaj dugotrajne dijetalne restrikcije na insulinski signalni put u mozgu pacova tokom starenjasr
dc.title.alternativeThe effect of long-term dietary restriction on insulin signaling pathway in rat brain during agingen
dc.typedoctoralThesis
dc.rights.licenseBY-NC-SA
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/1693/Disertacija.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/1694/IzvestajKomisije21108.pdf


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