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Sinteza 2',3'- dideoksinukleozida

The Synthesis of 2´, 3' - Dideoxynucleozides

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1998
Disertacija.pdf (56.04Mb)
IzvestajKomisije.pdf (3.932Mb)
Author
Ćetković, Gordana
Mentor
Lajšić, Stevan
Committee members
Milić, Božidar
Lajšić, Stevan
Popsavin, Velimir
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Abstract
U radu je ostvarena višefazna transformacija D-ksiloze u pogodno funkcionalizovane derivate koji su kuplovanjem sa siliranim timinom selektivno dali nukleozide sa beta-konfiguracijom na anomernom centru. Takođe, u cilju sinteze nukleozida L-serije, ispitana je mogućnost izomerizacije nekih derivata D-šečera u odgovarajuće L-stereoizomere.
Muitistep transformation of D-xylose to suitabte functional derivatives were achieved. Coupling of these derivatives with silylated thymine gave the nucleosides with beta-configuration on anomeric centre. In order to synthesis nucleosides of L-series, the possibility for isomerization of some kinds D-sugar derivatives in corresponding L-stereisomeric compounds, were investigatet, too.
Faculty:
University of Novi Sad, Faculty of Technology
Date:
18-12-1998
Keywords:
Sinteza / Synthesis / 2´ / 3'- dideoxynucleozides / D-xylose / 2´ / 3'- dideoksinukleozidi / D-ksiloza
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https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija153777435546335.pdf?controlNumber=(BISIS)71445&fileName=153777435546335.pdf&id=11984&source=NaRDuS&language=sr
http://nardus.mpn.gov.rs/handle/123456789/11362
https://www.cris.uns.ac.rs/record.jsf?recordId=71445&source=NaRDuS&language=sr
https://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije156819867553395.pdf?controlNumber=(BISIS)71445&fileName=156819867553395.pdf&id=13386&source=NaRDuS&language=sr

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