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Bihevioralni efekti dugotrajne primene dijetetskih protokola sa povećanim sadržajem metionina i nedostatkom folata, piridoksina i kobalamina kod pacova

Behavioral effects of long-term application of dietary protocols enriched with

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2019
Disertacija.pdf (13.02Mb)
Izvestaj Natasa Mijailovic Medicina.pdf (494.4Kb)
Author
Mijailović, Nataša
Mentor
Rosić, Gvozden
Committee members
Jakovljević, Vladimir
Mitrović, Dušan M.
Selaković, Dragica
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Abstract
SAŽETAK: Uvod: U ovoj studiji su ispitivani bihevioralni efekti dugotrajne primene dijetetskih protokola sa povećanim sadržajem metionina i nedostatkom folata, piridoksina i kobalamina, kao i uticaj primene statina uz navedene dijetetske protokole kod pacova. Materijal i metode: Studija je sprovedena na 72 pacova Wistar albino soja, starosti četiri nedelje, telesne mase 100±15g, podeljenih u 9 grupa, na osnovu primenjenih dijetetskih protokola - standardna hrana, hrana sa povećanim sadržajem metionina, hrana sa povećanim sadržajem metionina i smanjenim sadržajem folata, piridoksina i kobalamina. U odgovarajućim grupama uz navedene protokole, aplicirani su statini - atorvastatin (3 mg/kg) ili simvastatin (5 mg/kg). Protokoli su trajali 30 dana, nakon čega su vršeni bihevioralni testovi, a nakon toga su životinje žrtvovane u cilju dobijanja uzoraka za analizu parametara oksidativnog statusa u tkivu hipokampusa. Rezultati: Rezultati bihevioralnog ispitivanja su pokazali da p...rimenjeni dijetetski protokoli sa povećanim sadržajem metionina, kao i sa povećanim sadržajem metionina i nedostatkom vitamina V kompleksa (V6, V9, V12) dovode do ispoljavanja anksiogenog i prodepresantnog efekta. Istovremena primena statina uz navedene protokole je ublažavala negativne bihevioralne efekte dijetetskih režima. Parametri za procenu oksidativnog stresa u hipokampusu su potvrđivali oksidativno oštećenje uzrokovano dijetetskim protokolima, dok je simultana primena statina smanjivala oksidativno oštećenje hipokampalnog tkiva. Zaključak: Hronična primena dijete sa povećanim sadržajem metionina, kao i sa povećanim sadržajem metionina uz nedostatak vitamina V kompleksa (V6, V9, V12) je dovela do ispoljavanja anksiogenog i prodepresantnog efekta, uz istovremeno povećanje oksidativnog oštećenja u tkivu hipokampusa. Istovremena primena statina (atorvastatin i simvastatin) sprovođena uz dijetetski protokol sa povećanim unosom metionina, kao i uz dodatni nedostatak vitamina V kompleksa, je ublažavala negativne bihevioralne efekte izazvane dijetetskim protokolima, uz smanjenje stepena oksidativnog oštećenja tkiva hipokampusa.

ABSTRACT Introduction: The aim of this study was to evaluate behavioral effects of special dietary protocols enriched with methionine and deficient in folate, pyridoxine and cobalamine in rats. The effects of statins, simultaneously applied with special dietary protocols, were also investigated in this study. Material and methods: The investigation was performed on 72 male Wistar albino rats, 4 weeks old, 100 ± 15 g body weight. They were divided (eight per group) according to the basic dietary protocols: standard chow, methionine-enriched, and methionine-enriched vitamins B (B6, B9, B12) deficient diet. Each dietary protocol included groups with atorvastatin (3 mg/kg/day) and simvastatin (5 mg/kg/day). Applied dietary protocols lasted for 30 days. Behavioral testing was performed following completion of dietary pretreatment and parameters of oxidative stress were determined in hippocampal tissue samples following decapitation after anesthesia. Results: The results of beha...vioral testing showed that methionine-load dietary protocols, as well as methionine-enriched diet with restricted vitamins B intake, induced anxiogenic and prodepressant effects. Simultaneous statins administration attenuated negative behavioral effects of both applied dietary protocols. Parameters for oxidative stress estimation confirmed oxidative damage in rat hippocampus, while simultaneous application of statins attenuated oxidative damage caused by applied dietary protocols. Conclusion: Chronic dietary interventions enriched with methionine and deficient in folate, pyridoxine and cobalamine induced anxiogenic and prodepressant effects, which were accompanied by increased oxidative stress in rat hippocampus. Simultaneous statins administration with methionine overloading dietary protocols showed beneficial effects by means of attenuation of both negative behavioral effects and oxidative stress parameters in hippocampal tissue.

Faculty:
University of Kragujevac, Faculty of Medical Sciences
Date:
22-03-2019
Projects:
  • Pharmacological analysis of effects of biologically active substances on isolated smooth muscles from human gastrointestinal and urogenital tract (RS-175007)
Keywords:
homocistein / homocysteine / atorvastatin / simvastatin / anxiety / depression / oxidative stress / atorvastatin / simvastatin / anksioznost / depresija / oksidativni stres.
[ Google Scholar ]
URI
http://eteze.kg.ac.rs/application/showtheses?thesesId=6722
http://nardus.mpn.gov.rs/handle/123456789/11189
https://fedorakg.kg.ac.rs/fedora/get/o:1137/bdef:Content/download

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