Nova biološki aktivna sintetska azaheterociklična jedinjenja i novi sekundarni metaboliti iz odabranih biljnih vrsta: sinteza, izolovanje i spektralna karakterizacija

Abstract

The aim of this PhD thesis was the discovery of new biologically active compounds either by means of natural product isolation from selected plant taxa or by organic synthesis. All of the either isolated or synthesized compounds were characterized by spectroscopic methods, including one- and two-dimensional NMR experiments. The specific compounds that were the subject of this research were: aromatic esters from Ferula ovina (Apiaceae), octyl esters from Heracleum sphondylium (Apiaceae), diesters of an oxygenated germacrane derivative from Daucus carota (Apiaceae), isothiocyanates from Reseda lutea (Resedaceae) and germacrone epoxides from Geranium macrorrhizum (Geraniaceae). Also, as a part of this dissertation, a synthesis of new ferrocene-indole hybrids and the investigation of complex metal hydride reduction of Biginelli compounds was performed. A number of these compounds were tested for their biological activities (antimicrobial, cytotoxic, antinociceptive and antiacetylcholinesterase activities).