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Nova biološki aktivna sintetska azaheterociklična jedinjenja i novi sekundarni metaboliti iz odabranih biljnih vrsta: sinteza, izolovanje i spektralna karakterizacija

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Disertacija.pdf (7.850Mb)
Zlatkovic_Dragan_B.pdf (3.015Mb)
Author
Zlatković, Dragan B.
Mentor
Radulović, Niko
Committee members
Popsavin, Mirjana
Dekić, Vidoslav
Ilić-Tomić, Tatjana
Ranđelović, Pavle
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Abstract
The aim of this PhD thesis was the discovery of new biologically active compounds either by means of natural product isolation from selected plant taxa or by organic synthesis. All of the either isolated or synthesized compounds were characterized by spectroscopic methods, including one- and two-dimensional NMR experiments. The specific compounds that were the subject of this research were: aromatic esters from Ferula ovina (Apiaceae), octyl esters from Heracleum sphondylium (Apiaceae), diesters of an oxygenated germacrane derivative from Daucus carota (Apiaceae), isothiocyanates from Reseda lutea (Resedaceae) and germacrone epoxides from Geranium macrorrhizum (Geraniaceae). Also, as a part of this dissertation, a synthesis of new ferrocene-indole hybrids and the investigation of complex metal hydride reduction of Biginelli compounds was performed. A number of these compounds were tested for their biological activities (antimicrobial, cytotoxic, antinociceptive and antiace...tylcholinesterase activities).

Faculty:
Универзитет у Нишу, Природно-математички факултет
Date:
18-02-2019
Projects:
  • Science in Motion for Friday Night Commotion (EU-316471)
  • Combinatorial libraries of heterogeneous catalysts, natural products, and their derivatives and analogues: the way to biologically active compounds (RS-172061)
Keywords:
Organska sinteza / Organic synthesis / natural product isolation / spectral characterization / ferrocenes / indoles / Biginelli compounds / izolovanje prirodnih proizvoda / spektralna karakterizacija / feroceni / indoli / Biđinelijeva jedinjenja
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_11156
URI
https://nardus.mpn.gov.rs/handle/123456789/11156
http://eteze.ni.ac.rs/application/showtheses?thesesId=6699
https://fedorani.ni.ac.rs/fedora/get/o:1575/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1025773289

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