Приказ основних података о дисертацији

dc.contributor.advisorJovanović, Goran
dc.contributor.otherLazić, Zoran
dc.creatorTodorović, Kosta M.
dc.date.accessioned2018-12-28T09:14:44Z
dc.date.available2018-12-28T09:14:44Z
dc.date.available2020-07-03T16:08:29Z
dc.date.issued2018-09-06
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=6397
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/10550
dc.identifier.urihttps://fedorani.ni.ac.rs/fedora/get/o:1528/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1026120173
dc.description.abstractThe process of wound healing has a high significance in dental practice. The application of numerous antioxidants can significantly improve the process and greatly contribute to the quality of patient recovery after the intervention. In the experimental study with Wistar rats, the upper incisors were extracted and after that the solutions of coenzyme Q10 and curcumin in its free and nanoliposome-encapsulated form were applied. The extraction wounds were treated with the stated solutions for 21 days. The use of antioxidants such as Q10 and curcumin has significantly contributed to the improvement of the course of wound healing during teeth extraction in experimental animals. It needs to be emphasized that the best results were obtained by local application of coenzyme Q10 and nanoliposome-encapsulated curcumin. This application has reduced inflammation and accelerated cellular proliferation which is necessary for regeneration of damaged tissue. In addition, one of the aims of the doctoral thesis was to analyze the expression of osteopontin, a glycoprotein with important roles in inflammation and biomineralization. The immunohistochemical analysis showed a significantly lower expression in the tissues treated with nanoliposome-encapsulated antioxidants, compared to the control and other experimental groups of animals. The analysis of the level of oxidative stress parameters (MDA, AOPP, catalysis) showed that the application of antioxidants in both forms greatly contributed to the prevention of damage caused by oxygen bond production. All the results obtained in the doctoral thesis are presented in tables, graphs and are documented with images of pathohistological tissue analysis. The obtained results of the thesis can be used as a starting point in the application of these antioxidants in clinical practice in order to accelerate the process of wound healing, as well as to reduce the development of complications after teeth extraction.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Медицински факултетsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Нишуsr
dc.subjectZarastanje ranesr
dc.subjectWound healingen
dc.subjectcoenzyme Q10en
dc.subjectcurcuminen
dc.subjectnanoliposomesen
dc.subjectosteopontinen
dc.subjectoxidative stressen
dc.subjectkoenzim Q10sr
dc.subjectkurkuminsr
dc.subjectnanolipozomisr
dc.subjectosteopontinsr
dc.subjectoksidativni stressr
dc.titleEfikasnost koenzima Q10 i kurkumina enkapsuliranih nanolipozome kod zarastanja mekih tkiva nakon ektrakcije zuba: ekperomntalna sudijasr
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/53611/Disertacija.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/53612/Todorovic_Kosta_M.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/53611/Disertacija.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/53612/Todorovic_Kosta_M.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_10550


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Приказ основних података о дисертацији