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dc.contributor.advisorMirković, Darko
dc.contributor.otherRadovanović, Dragče
dc.contributor.otherArsenijević, Nebojša
dc.contributor.otherTrifunović, Bratislav
dc.creatorJovanović, Milan
dc.date.accessioned2018-12-27T12:17:03Z
dc.date.available2018-12-27T12:17:03Z
dc.date.available2020-07-03T15:14:47Z
dc.date.issued2018-05-29
dc.identifier.urihttp://eteze.kg.ac.rs/application/showtheses?thesesId=6075
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/10523
dc.identifier.urihttps://fedorakg.kg.ac.rs/fedora/get/o:1019/bdef:Content/download
dc.description.abstractKolorektalni karcinom (engl. Colorecral carcinoma- CRC) je jedan od najučestalijih karcinoma na svetu. CRC se često dijagnostikuje u uznapredovalim stadijumima sa lošom prognozom, ukazujući na potrebu za novim dijagnostičkim i prognostičkim markerima. Cilj studije bio je da se ispita povezanost vrednosti citokina u serumu i fecesu sa stadijumom bolesti i kliničko-patološkim karakteristikama, kod pacijenata sa kolorektalnim karcinomom. Detektovana je značajno veća fecesna koncentracija Gal-3 kod pacijenata sa CRC-om sa većom nuklearnim gradusom, slabom diferencijacijom tumorskog tkiva, većim TNM stadijumom i metastatskom bolešću, dok je predominacija Gal-3 nad proinflamacijskim citokinima zabeležena kod pacijenata sa uznapredovalim TNM stadijumom i metastatskom bolesti. Fecesni Gal-3 pozitivno korelira s težinom bolesti (veći TNM stadijum, veći nuklearni gradus i slaba diferencijacija tumorskog tkiva) i progresijom (prisustvo metastaza u plućima/jetri ili peritonealne karcinomatoze) i sistemskih biomarkera AFP i CEA. Ovi nalazi ukazuju na Gal 3 kao potencijalni marker težine i progresije CRC-a. Takođe je pokazana povećana koncentracija Gal-1 u fecesu pacijenata sa CRC-om i većim nuklearnim gradusom i slabom diferencijacijom tumorskog tkiva, dok je predominacija Gal-1 u odnosu na proinflamacijske citokine detektovana kod pacijenata sa uznapredovaim TNM stadijumom i metastatskom bolešću. Predominacija Gal-1 i Gal-3 u odnosu na proinflamacijske citokine, kod ispitanika sa naprednom i progresivnom bolešću, može ukazati na imunomodulatornu ulogu galektina u ograničavanju kontinuiranih proinflamacijskih procesa i sprečavanju snažnog antitumorskog imunskog odgovora. Fekalne vrednosti Gal-1 i Gal-3 mogu se koristiti kao značajan marker za težinu i progresiju CRC-a. Ovi nalazi ukazuju da Gal-1 i Gal-3 mogu doprineti imunološkoj privilegiji tumora modulacijom lokalnog imunskog odgovora i ukazuju na njihovu potencijalnu upotrebu kao terapeutskih meta.sr
dc.description.abstractColorectal cancer (CRC) represents one of the most common cancers worldwide. CRC is frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers. The aim of the study was to investigate the correlation between the level of cytokines in serum and faeces with the stage of the disease and the clinical and pathological characteristics in patients with colorectal carcinoma. Significantly higher fecal Gal-3 was observed in patients with CRC with higher nuclear grade, poor tumor differentiation, higher TNM stage and metastatic disease, while Gal-3 predominance over proinflammatory cytokines was observed in patients with advanced TNM and metastatic diseases. Fecal Gal-3 positively correlates with the severity of the disease (higher TNM stage, higher nuclear grade and poor tumor tissue differentiation) and progression (presence of lung/liver metastatsis or peritoneal carcinomatosis) and systemic biomarkers AFP and CEA. These findings indicate Gal 3 as a potential marker of the severity and progression of CRC. An increased Gal-1 concentration in feces of patients with CRC and a higher nuclear grade and a poorly differentiated tumor tissue was observed, while Gal-1 prevalence over proinflammatory cytokines was detected in patients with advanced TNM and metastatic disease. The prevalence of Gal-1 and Gal-3 over proinflammatory cytokines, in subjects with advanced and progressive disease, may indicate the immunomodulatory role of galectins in limiting ongoing proinflammatory processes and thus preventing a strong antitumor immune response. The fecal values of Gal-1 and Gal-3 can be used as a significant marker for severity and progression of the CRC. These findings indicate that Gal-1 and Gal-3 can contribute to the immune privileges of the tumor by modulating the local immune response and point to their potential use as therapeutic targets.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Крагујевцу, Факултет медицинских наукаsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175069/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175071/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175103/RS//
dc.rightsopenAccessen
dc.sourceУниверзитет у Крагујевцуsr
dc.subjectKolorektalni karcinomsr
dc.subjectColorectal carcinomaen
dc.subjecttežina bolestisr
dc.subjectimunski odgovorsr
dc.subjectdisease severityen
dc.subjectimmune responseen
dc.titleKolorektalni karcinom: značaj koncentracija citokina u serumu i fecesu za procenu težine bolestisr
dc.typedoctoralThesis
dc.rights.licenseBY-NC-ND
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/48422/Disertacija.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/48423/Milan_Jovanovic_Medicina.pdf


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