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Farmakologija i toksikološki profil novosintetisanih derivata hromana-2,4-diona u funkciji antikoagulativne aktivnosti in vivo

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2018
Disertacija.pdf (120.6Mb)
Nevena_Stankovic_PMF.pdf (4.377Mb)
Author
Stanković, Nevena
Mentor
Mladenović, Milan
Committee members
Kostić, Danijela A.
Mihailović, Mirjana.
Vuković, Nenad
Mihailović, Vladimir
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Abstract
Priloženi rukopis sumira sintezu šest novih derivata 3-(1-aminoetiliden) hroman-2,4-diona, označenih kao 2a-f, i dva nova derivata 4-hidroksi-3-(1-imino- etil)-2H-hromen-2-ona označenih kao 2g-h, odnosno evaluaciju njihove in vivo anti- koagulativne aktivnosti nakon intraperitonealne i oralne aplikacije na odraslim pacovima Wistar soja, sa ciljem procene njihovog kliničkog antikoagulativnog potencijala, farmakologije i toksičnosti.
The enclosed manuscript summarizes the efforts of synthesis and evaluation of six novel 3-(1-aminoethylidene)chromane-2,4-diones, namely 2a-f, as well as of two novel 4- hydroxy-3-(1-iminoethyl)-2H-chromene-2-one derivatives, namely 2g-h, as in vivo anticoagulants by means of intraperitoneal and per os administration to adult male Wistar rats. Condensates were screened to expose their anticoagulant potential, pharmacology and toxicity.
Faculty:
Универзитет у Крагујевцу, Природно-математички факултет
Date:
01-06-2018
Projects:
  • Simultaneous Bioremediation and Soilification of Degraded Areas to Preserve Natural Resources of Biologically Active Substances, and Development and Production of Biomaterials and Dietetic Products (RS-43004)
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_10487
URI
http://eteze.kg.ac.rs/application/showtheses?thesesId=6061
https://nardus.mpn.gov.rs/handle/123456789/10487
https://fedorakg.kg.ac.rs/fedora/get/o:1008/bdef:Content/download

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