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Značaj galektina-1 kao prognostičkog faktora u lečenju klasičnog Hočkinovog limfoma

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2018
Disertacija.pdf (3.939Mb)
Simonovic_Olivera_B.pdf (1010.Kb)
Doktorand
Simonović, Olivera B.
Mentor
Marjanović, Goran
Članovi komisije
Mačukanović-Golubović, Lana
Jevtović-Stoimenov, Tatjana
Mihaljević, Biljana
Metapodaci
Prikaz svih podataka o disertaciji
Sažetak
In classical Hodgkin’s lymphoma (cHL) the existing prognostic scoring systems do not include markers that adequately reflect the interaction of malignant Hodgkin and Reed-Sternberg (HRS) cells and tumor environment. The research objective is to determine the relationship between serum Galectin-1 (Gal-1) and soluble CD163 (sCD163) and the clinical status of patients with cHL, with special emphasis on the presence of relapse, progression, or resistance to the therapy applied. The research included 79 patients. Of this number, 63 were patients with cHL, and the control group consisted of 16 healthy volunteers. The study group of 63 patients with cHL included a subgroup of newly diagnosed patients without therapy, newly diagnosed patients with therapy, patients with relapse and progression of the disease, and primary refractory patients during 2014 and 2015. Analysis of the levels of sCD163 and sGal-1 within a group of patients suffering from cHL has shown that the values of ...both molecules were higher in relapsed patients and the subgroup with progressive disease comparing the subgroup of newly diagnosed patients without therapy or patients with therapy onset. Determination of Gal-1 and sCD163 levels is simple and reliable analysis that can contribute to the identification of high-risk patients with cHL, and deserves inclusion in current prognostic scoring systems.

Fakultet:
Универзитет у Нишу, Медицински факултет
Datum odbrane:
27-02-2018
Ključne reči:
Hoĉkinov limfom / Hodgkin’s lymphoma / Internacionalni prognostiĉki skor / sCD163 / Gal-1 / International prognostic score / Gal-1 / sCD163
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_10453
Ostali linkovi:
https://nardus.mpn.gov.rs/handle/123456789/10453
http://eteze.ni.ac.rs/application/showtheses?thesesId=5832
https://fedorani.ni.ac.rs/fedora/get/o:1478/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1025977325

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