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Sinteza i antitumorski potencijal C19-derivatizovanih steroidnih D-homo laktona

Synthesis and antitumor potential of C19-derivatized steroidal D-homo lactones

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2018
Disertacija.pdf (12.08Mb)
IzvestajKomisije.pdf (445.5Kb)
Author
Kuzminac, Ivana
Mentor
Sakač, Marija
Committee members
Popsavin, Mirjana
Sakač, Marija
Petri, Edward
Nikolić, Andrea
Jakimov, Dimitar
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Abstract
U  ovom  radu  ostvarene  su  sinteze C19-derivatizovanih  steroidnih  D-homo laktona.  Takođe,  sintetisani  su  i  5,6-halogeni derivati,  5,6-supstituisani  kiseonični  derivati, kao  i  6,19-epoksi  steroidi.  Za  sva  sintetisana jedinjenja  je  utvrđen  antitumorski  potencijal ispitivanjem  njihove  oralne  bioraspoloživosti, antiproliferativne  aktivnosti  na  šest  ćelijskih linija  kancera,  vezivanja  za  odabrane  steroidne receptore  i  inhibitorne  aktivnosti  na  enzim AKR1C3.
In  this  paper,  a  synthesis  of  C19-derivatized steroidal D-homo lactones has been conducted. 5,6-Halogen derivatives, 5,6-substituted oxygen derivatives  and  6,19-epoxy  steroids  were  also synthesized.  Antitumor  potential  was determined  for  all  synthesized  compounds  by examining  their  oral  bioavailability, antiproliferative activity on six cancer cell lines, binding  to  selected  steroid  receptors  and inhibitor activity on the AKR1C3 enzyme.
Faculty:
Универзитет у Новом Саду, Природно-математички факултет
Date:
28-09-2018
Projects:
  • Synthesis, characterization and biological investigation of steroid derivatives and their molecular aggregates (RS-172021)
Keywords:
Sinteza / Synthesis / D-homo steroids / androgen / antiproliferative activity / D-homo steroidi / androgeni / antiproliferativna aktivnost
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_nardus_10364
URI
https://nardus.mpn.gov.rs/handle/123456789/10364
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